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ACTG1

GENERAL INFORMATION

Gene name

 ACTG1

Gene description

 Actin gamma 1

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression of myoepithelial cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Approved based on 2 antibodies.
HPA041264 , HPA041271
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (favourable).
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Pancreatic cancer

STAINING SUMMARY
HPA041264
HPA041271

GENE INFORMATION

Gene name

 ACTG1 (HGNC Symbol)

Synonyms

 ACTG, DFNA20, DFNA26

Description

 Actin gamma 1 (HGNC Symbol)

Entrez gene summary

 Actins are highly conserved proteins that are involved in various types of cell motility, and maintenance of the cytoskeleton. In vertebrates, three main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton, and as mediators of internal cell motility. Actin, gamma 1, encoded by this gene, is a cytoplasmic actin found in non-muscle cells. Mutations in this gene are associated with DFNA20/26, a subtype of autosomal dominant non-syndromic sensorineural progressive hearing loss. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2011]

Chromosome

 17

Cytoband

 q25.3

Chromosome location (bp)

 81509971 - 81523847

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000184009 (version 83.38)

Entrez gene

 71

UniProt

 P63261 (UniProt - Evidence at protein level)

neXtProt

 NX_P63261

Antibodypedia

 ACTG1 antibodies

PROTEIN BROWSER
ACTG1-001
ACTG1-002
ACTG1-003
ACTG1-010
ACTG1-011
ACTG1-012
ACTG1-013
ACTG1-014
ACTG1-017
ACTG1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ACTG1-001
ENSP00000331514
ENST00000331925
P63261 [Direct mapping]
Actin, cytoplasmic 2 Actin, cytoplasmic 2, N-terminally processed
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001895 [retina homeostasis]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006928 [movement of cell or subcellular component]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0016020 [membrane]
GO:0031625 [ubiquitin protein ligase binding]
GO:0034329 [cell junction assembly]
GO:0034332 [adherens junction organization]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042802 [identical protein binding]
GO:0045087 [innate immune response]
GO:0045216 [cell-cell junction organization]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0070527 [platelet aggregation]
GO:0072562 [blood microparticle]
GO:0097433 [dense body]
Show all
 375 aa
41.8 kDa 		No 0
ACTG1-002
ENSP00000459124
ENST00000575087
P63261 [Direct mapping]
Actin, cytoplasmic 2 Actin, cytoplasmic 2, N-terminally processed
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001895 [retina homeostasis]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006928 [movement of cell or subcellular component]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0016020 [membrane]
GO:0031625 [ubiquitin protein ligase binding]
GO:0034329 [cell junction assembly]
GO:0034332 [adherens junction organization]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042802 [identical protein binding]
GO:0045087 [innate immune response]
GO:0045216 [cell-cell junction organization]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0070527 [platelet aggregation]
GO:0072562 [blood microparticle]
GO:0097433 [dense body]
Show all
 375 aa
41.8 kDa 		No 0
ACTG1-003
ENSP00000458435
ENST00000573283
P63261 [Direct mapping]
Actin, cytoplasmic 2 Actin, cytoplasmic 2, N-terminally processed
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001895 [retina homeostasis]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006928 [movement of cell or subcellular component]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0016020 [membrane]
GO:0031625 [ubiquitin protein ligase binding]
GO:0034329 [cell junction assembly]
GO:0034332 [adherens junction organization]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042802 [identical protein binding]
GO:0045087 [innate immune response]
GO:0045216 [cell-cell junction organization]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0070527 [platelet aggregation]
GO:0072562 [blood microparticle]
GO:0097433 [dense body]
Show all
 375 aa
41.8 kDa 		No 0
ACTG1-010
ENSP00000459119
ENST00000575659
I3L1U9 [Direct mapping]
Actin, cytoplasmic 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 214 aa
23.8 kDa 		No 0
ACTG1-011
ENSP00000460464
ENST00000575994
I3L3I0 [Direct mapping]
Actin, cytoplasmic 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 214 aa
23.8 kDa 		No 0
ACTG1-012
ENSP00000458162
ENST00000575842
P63261 [Direct mapping]
Actin, cytoplasmic 2 Actin, cytoplasmic 2, N-terminally processed
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001895 [retina homeostasis]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006928 [movement of cell or subcellular component]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0030016 [myofibril]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031941 [filamentous actin]
GO:0034329 [cell junction assembly]
GO:0034332 [adherens junction organization]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042802 [identical protein binding]
GO:0043209 [myelin sheath]
GO:0045087 [innate immune response]
GO:0045214 [sarcomere organization]
GO:0045216 [cell-cell junction organization]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0070527 [platelet aggregation]
GO:0072562 [blood microparticle]
GO:0097433 [dense body]
Show all
 375 aa
41.8 kDa 		No 0
ACTG1-013
ENSP00000460660
ENST00000571721
I3L3R2 [Direct mapping]
Actin, cytoplasmic 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 164 aa
18 kDa 		No 0
ACTG1-014
ENSP00000466346
ENST00000570382
K7EM38 [Direct mapping]
Actin, cytoplasmic 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 133 aa
14.5 kDa 		No 0
ACTG1-017
ENSP00000461407
ENST00000571691
I3L4N8 [Direct mapping]
Actin, cytoplasmic 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 242 aa
26.9 kDa 		No 0
ACTG1-201
ENSP00000477968
ENST00000615544
P63261 [Direct mapping]
Actin, cytoplasmic 2 Actin, cytoplasmic 2, N-terminally processed
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001895 [retina homeostasis]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006928 [movement of cell or subcellular component]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007411 [axon guidance]
GO:0016020 [membrane]
GO:0031625 [ubiquitin protein ligase binding]
GO:0034329 [cell junction assembly]
GO:0034332 [adherens junction organization]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0042802 [identical protein binding]
GO:0045087 [innate immune response]
GO:0045216 [cell-cell junction organization]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0070527 [platelet aggregation]
GO:0072562 [blood microparticle]
GO:0097433 [dense body]
Show all
 375 aa
41.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.