Expression of FAM120C in cancer - Summary - The Human Protein Atlas

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FAM120C

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FAM120C
Gene description	Family with sequence similarity 120C
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and/or nuclear expression in selected tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA047677
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (favourable).
Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA047677

GENE INFORMATION
Gene name	FAM120C (HGNC Symbol)
Synonyms	CXorf17, FLJ20506, ORF34
Description	Family with sequence similarity 120C (HGNC Symbol)
Entrez gene summary	This gene encodes a potential transmembrane protein and lies in a region where mutations and deletions have been associated with intellectual disability and autism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Chromosome	X
Cytoband	p11.22
Chromosome location (bp)	54068324 - 54183281
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000184083 (version 83.38)
Entrez gene	54954
UniProt	Q9NX05 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9NX05
Antibodypedia	FAM120C antibodies

PROTEIN BROWSER

FAM120C-001	FAM120C-003	FAM120C-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FAM120C-001 ENSP00000364324 ENST00000375180	Q9NX05 [Direct mapping] Constitutive coactivator of PPAR-gamma-like protein 2 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0044822 [poly(A) RNA binding] Show all	1096 aa 120.6 kDa	No	0
FAM120C-003 ENSP00000329896 ENST00000328235	F8W881 [Direct mapping] Constitutive coactivator of PPAR-gamma-like protein 2 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		895 aa 99.4 kDa	No	0
FAM120C-004 ENSP00000420718 ENST00000477084	Q9NX05 [Direct mapping] Constitutive coactivator of PPAR-gamma-like protein 2 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0044822 [poly(A) RNA binding] Show all	238 aa 25.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.