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Group enriched (brain, caudate, cerebellum, hippocampus)
Protein evidence
Evidence at protein level
Protein expression
Cytoplasmic expression in CNS.
DATA RELIABILITY
Data reliability description
Antibody staining mainly not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
RNA tissue category: Group enriched (brain, caudate, cerebellum, hippocampus)
GENE INFORMATION
Gene name
CNTN2 (HGNC Symbol)
Synonyms
AXT, TAG-1, TAX, TAX1
Description
Contactin 2 (axonal) (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. It may also be involved in glial tumorigenesis and may provide a potential target for therapeutic intervention. [provided by RefSeq, Jul 2008]
Transporters Accessory Factors Involved in Transport Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization] GO:0001764 [neuron migration] GO:0001948 [glycoprotein binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0007160 [cell-matrix adhesion] GO:0007409 [axonogenesis] GO:0007411 [axon guidance] GO:0007413 [axonal fasciculation] GO:0007612 [learning] GO:0007628 [adult walking behavior] GO:0008076 [voltage-gated potassium channel complex] GO:0009986 [cell surface] GO:0010769 [regulation of cell morphogenesis involved in differentiation] GO:0010954 [positive regulation of protein processing] GO:0021853 [cerebral cortex GABAergic interneuron migration] GO:0022010 [central nervous system myelination] GO:0030246 [carbohydrate binding] GO:0030424 [axon] GO:0031133 [regulation of axon diameter] GO:0031175 [neuron projection development] GO:0031225 [anchored component of membrane] GO:0031623 [receptor internalization] GO:0033268 [node of Ranvier] GO:0042802 [identical protein binding] GO:0043005 [neuron projection] GO:0043025 [neuronal cell body] GO:0043209 [myelin sheath] GO:0043621 [protein self-association] GO:0044224 [juxtaparanode region of axon] GO:0045163 [clustering of voltage-gated potassium channels] GO:0045202 [synapse] GO:0045665 [negative regulation of neuron differentiation] GO:0048168 [regulation of neuronal synaptic plasticity] GO:0048710 [regulation of astrocyte differentiation] GO:0060168 [positive regulation of adenosine receptor signaling pathway] GO:0071205 [protein localization to juxtaparanode region of axon] GO:0071206 [establishment of protein localization to juxtaparanode region of axon] GO:0097090 [presynaptic membrane organization]
