Expression of LRTOMT in cancer - Summary

GENERAL INFORMATION
Gene name	LRTOMT
Gene description	Leucine rich transmembrane and O-methyltransferase domain containing
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	18
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in most tissues, most abundant in fallopian tube.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending retesting.
Reliability score	Approved based on 1 antibody. HPA039949
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PROGNOSTIC SUMMARY
Prognostic marker in ovarian cancer (favourable) and endometrial cancer (favourable).
Ovarian cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA039949

GENE INFORMATION
Gene name	LRTOMT (HGNC Symbol)
Synonyms	CFAP111, COMT2, DFNB63, LRRC51
Description	Leucine rich transmembrane and O-methyltransferase domain containing (HGNC Symbol)
Entrez gene summary	This gene includes two transcript forms. The short form has one open reading frame (ORF), which encodes the leucine-rich repeats (LRR)-containing protein of unknown function. This protein is called LRTOMT1 or LRRC51. The long form has two alternative ORFs; the upstream ORF has the same translation start codon as used in the short form and the resulting transcript is a candidate for nonsense-mediated decay, and the downstream ORF encodes a different protein, which is a transmembrane catechol-O-methyltransferase and is called LRTOMT2, TOMT or COMT2. The COMT2 is essential for auditory and vestibular function. Defects in the COMT2 can cause nonsyndromic deafness. Alternatively spliced transcript variants from each transcript form have been found for this gene. [provided by RefSeq, Sep 2012]
Chromosome	11
Cytoband	q13.4
Chromosome location (bp)	72080331 - 72110782
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000184154 (version 83.38)
Entrez gene	220074
UniProt	Q8WZ04 (UniProt - Evidence at protein level), Q96E66 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8WZ04, NX_Q96E66
Antibodypedia	LRTOMT antibodies

PROTEIN BROWSER

LRTOMT-001	LRTOMT-002	LRTOMT-003	LRTOMT-004	LRTOMT-006	LRTOMT-010	LRTOMT-011	LRTOMT-012	LRTOMT-014	LRTOMT-015	LRTOMT-016	LRTOMT-018	LRTOMT-020	LRTOMT-201	LRTOMT-202	LRTOMT-203	LRTOMT-204	LRTOMT-205

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LRTOMT-001 ENSP00000289488 ENST00000289488	Q96E66 [Direct mapping] Leucine-rich repeat-containing protein 51 A0A024R5L6 [Target identity:100%; Query identity:100%] Leucine rich repeat containing 51, isoform CRA_a Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0008171 [O-methyltransferase activity] GO:0032259 [methylation] Show all	192 aa 22.2 kDa	No	0
LRTOMT-002 ENSP00000395139 ENST00000439209	C9JDG7 [Direct mapping] Leucine-rich repeat-containing protein 51 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0008171 [O-methyltransferase activity] GO:0032259 [methylation] Show all	156 aa 18 kDa	No	0
LRTOMT-003 ENSP00000441249 ENST00000423494	Q96E66 [Direct mapping] Leucine-rich repeat-containing protein 51 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0008171 [O-methyltransferase activity] GO:0032259 [methylation] Show all	174 aa 20 kDa	No	0
LRTOMT-004 ENSP00000437649 ENST00000539587	F5H6F7 [Direct mapping] Leucine-rich repeat-containing protein 51 Show all	Predicted intracellular proteins Show all		43 aa 4.5 kDa	No	0
LRTOMT-006 ENSP00000440693 ENST00000324866	Q96E66 [Direct mapping] Leucine-rich repeat-containing protein 51 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0008171 [O-methyltransferase activity] GO:0032259 [methylation] Show all	146 aa 16.8 kDa	No	0
LRTOMT-010 ENSP00000438522 ENST00000541614	Q96E66 [Direct mapping] Leucine-rich repeat-containing protein 51 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0008171 [O-methyltransferase activity] GO:0032259 [methylation] Show all	158 aa 18.1 kDa	No	0
LRTOMT-011 ENSP00000438762 ENST00000538413	F5H0M6 [Direct mapping] Leucine-rich repeat-containing protein 51 Show all	Predicted intracellular proteins Show all		92 aa 10.7 kDa	No	0
LRTOMT-012 ENSP00000442267 ENST00000539271	F5H6F7 [Direct mapping] Leucine-rich repeat-containing protein 51 Show all	Predicted intracellular proteins Show all		43 aa 4.5 kDa	No	0
LRTOMT-014 ENSP00000444583 ENST00000538478	Q96E66 [Direct mapping] Leucine-rich repeat-containing protein 51 A0A024R5L6 [Target identity:100%; Query identity:100%] Leucine rich repeat containing 51, isoform CRA_a Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0008171 [O-methyltransferase activity] GO:0032259 [methylation] Show all	192 aa 22.2 kDa	No	0
LRTOMT-015 ENSP00000440248 ENST00000542846	F5GYI0 [Direct mapping] Leucine-rich repeat-containing protein 51 Show all	Predicted intracellular proteins Show all	GO:0008171 [O-methyltransferase activity] GO:0032259 [methylation] Show all	104 aa 12.1 kDa	No	0
LRTOMT-016 ENSP00000443421 ENST00000536917	Q96E66 [Direct mapping] Leucine-rich repeat-containing protein 51 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0008171 [O-methyltransferase activity] GO:0032259 [methylation] Show all	146 aa 16.8 kDa	No	0
LRTOMT-018 ENSP00000437985 ENST00000537483	F5H614 [Direct mapping] Leucine-rich repeat-containing protein 51 Show all	Predicted intracellular proteins Show all		65 aa 7.5 kDa	No	0
LRTOMT-020 ENSP00000390485 ENST00000440313	F8WBA5 [Direct mapping] Leucine-rich repeat-containing protein 51 Show all	Predicted intracellular proteins Show all		47 aa 5.1 kDa	No	0
LRTOMT-201 ENSP00000305742 ENST00000307198	Q8WZ04 [Direct mapping] Transmembrane O-methyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0005575 [cellular_component] GO:0005737 [cytoplasm] GO:0007605 [sensory perception of sound] GO:0008171 [O-methyltransferase activity] GO:0016021 [integral component of membrane] GO:0016206 [catechol O-methyltransferase activity] GO:0032259 [methylation] GO:0042135 [neurotransmitter catabolic process] GO:0042424 [catecholamine catabolic process] GO:0060117 [auditory receptor cell development] Show all	291 aa 32.2 kDa	No	1
LRTOMT-202 ENSP00000392233 ENST00000419228	A0A0C3SFZ6 [Direct mapping] Leucine-rich repeat-containing protein 51 Show all	Predicted intracellular proteins Show all	GO:0008171 [O-methyltransferase activity] GO:0032259 [methylation] Show all	155 aa 17.4 kDa	No	0
LRTOMT-203 ENSP00000409789 ENST00000435085	Q8WZ04 [Direct mapping] Transmembrane O-methyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Show all	GO:0005575 [cellular_component] GO:0005737 [cytoplasm] GO:0007605 [sensory perception of sound] GO:0008171 [O-methyltransferase activity] GO:0016021 [integral component of membrane] GO:0016206 [catechol O-methyltransferase activity] GO:0032259 [methylation] GO:0042135 [neurotransmitter catabolic process] GO:0042424 [catecholamine catabolic process] GO:0060117 [auditory receptor cell development] Show all	291 aa 32.2 kDa	No	1
LRTOMT-204 ENSP00000414271 ENST00000447974	Q96E66 [Direct mapping] Leucine-rich repeat-containing protein 51 A0A024R5L6 [Target identity:100%; Query identity:100%] Leucine rich repeat containing 51, isoform CRA_a Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0008171 [O-methyltransferase activity] GO:0032259 [methylation] Show all	192 aa 22.2 kDa	No	0
LRTOMT-205 ENSP00000482923 ENST00000615940	Q96E66 [Direct mapping] Leucine-rich repeat-containing protein 51 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0008171 [O-methyltransferase activity] GO:0032259 [methylation] Show all	174 aa 20 kDa	No	0