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Few squamous cell carcinomas of uterine cervix showed moderate to strong cytoplasmic positivity. Few colorectal and skin cancers along with hepatocellular carcinomas showed weak to moderate staining. Other cancers were negative.
GENE INFORMATION
Gene name
ADRA2C (HGNC Symbol)
Synonyms
ADRA2L2, ADRA2RL2, ADRARL2
Description
Adrenoceptor alpha 2C (HGNC Symbol)
Entrez gene summary
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]