Expression of CRELD2 in cancer - Summary - The Human Protein Atlas

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CRELD2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CRELD2
Gene description	Cysteine-rich with EGF-like domains 2
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in a majority of tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Approved based on 2 antibodies. HPA000603 , CAB025604
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and endometrial cancer (favourable).
Renal cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA000603	CAB025604

GENE INFORMATION
Gene name	CRELD2 (HGNC Symbol)
Synonyms	MGC11256
Description	Cysteine-rich with EGF-like domains 2 (HGNC Symbol)
Entrez gene summary
Chromosome	22
Cytoband	q13.33
Chromosome location (bp)	49918167 - 49927540
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000184164 (version 83.38)
Entrez gene	79174
UniProt	Q6UXH1 (UniProt - Evidence at protein level)
neXtProt	NX_Q6UXH1
Antibodypedia	CRELD2 antibodies

PROTEIN BROWSER

CRELD2-001	CRELD2-002	CRELD2-003	CRELD2-005	CRELD2-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CRELD2-001 ENSP00000332223 ENST00000328268	Q6UXH1 [Direct mapping] Cysteine-rich with EGF-like domain protein 2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] Show all	353 aa 38.2 kDa	Yes	0
CRELD2-002 ENSP00000383938 ENST00000404488	Q6UXH1 [Direct mapping] Cysteine-rich with EGF-like domain protein 2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] Show all	402 aa 43.6 kDa	Yes	0
CRELD2-003 ENSP00000386034 ENST00000407217	Q6UXH1 [Direct mapping] Cysteine-rich with EGF-like domain protein 2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] Show all	321 aa 35 kDa	Yes	0
CRELD2-005 ENSP00000384111 ENST00000403427	Q6UXH1 [Direct mapping] Cysteine-rich with EGF-like domain protein 2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] Show all	325 aa 35.3 kDa	Yes	0
CRELD2-008 ENSP00000387769 ENST00000450207	A6PWM2 [Direct mapping] Cysteine-rich with EGF-like domain protein 2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	229 aa 25.1 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.