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TSPYL2

GENERAL INFORMATION

Gene name

 TSPYL2

Gene description

 TSPY-like 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear and cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA044133
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable), renal cancer (unfavourable) and colorectal cancer (unfavourable).
Pancreatic cancer p<0.001
Renal cancer p<0.001
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA044133

GENE INFORMATION

Gene name

 TSPYL2 (HGNC Symbol)

Synonyms

 CDA1, CINAP, CTCL, DENTT, HRIHFB2216, SE20-4, TSPX

Description

 TSPY-like 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the testis-specific protein Y-encoded, TSPY-like/SET/nucleosome assembly protein-1 superfamily. The encoded protein is localized to the nucleolus where it functions in chromatin remodeling and as an inhibitor of cell-cycle progression. This protein may play a role in the suppression of tumor growth. [provided by RefSeq, Sep 2009]

Chromosome

 X

Cytoband

 p11.22

Chromosome location (bp)

 53082367 - 53088540

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000184205 (version 83.38)

Entrez gene

 64061

UniProt

 Q9H2G4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H2G4

Antibodypedia

 TSPYL2 antibodies

PROTEIN BROWSER
TSPYL2-001
TSPYL2-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TSPYL2-001
ENSP00000364591
ENST00000375442
Q9H2G4 [Direct mapping]
Testis-specific Y-encoded-like protein 2
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000182 [rDNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005886 [plasma membrane]
GO:0006334 [nucleosome assembly]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007049 [cell cycle]
GO:0008156 [negative regulation of DNA replication]
GO:0009966 [regulation of signal transduction]
GO:0016568 [chromatin modification]
GO:0030308 [negative regulation of cell growth]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0044267 [cellular protein metabolic process]
GO:0045786 [negative regulation of cell cycle]
GO:0045859 [regulation of protein kinase activity]
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 693 aa
79.4 kDa 		No 0
TSPYL2-005
ENSP00000462287
ENST00000579390
J3KS33 [Direct mapping]
Testis-specific Y-encoded-like protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005886 [plasma membrane]
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 250 aa
28.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.