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IRAK1

GENERAL INFORMATION

Gene name

 IRAK1

Gene description

 Interleukin-1 receptor-associated kinase 1

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA054476 , CAB004461
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Ovarian cancer

STAINING SUMMARY
HPA054476
CAB004461

GENE INFORMATION

Gene name

 IRAK1 (HGNC Symbol)

Synonyms

 IRAK, pelle

Description

 Interleukin-1 receptor-associated kinase 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 X

Cytoband

 q28

Chromosome location (bp)

 154010500 - 154019980

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000184216 (version 83.38)

Entrez gene

 3654

UniProt

 P51617 (UniProt - Evidence at protein level)

neXtProt

 NX_P51617

Antibodypedia

 IRAK1 antibodies

PROTEIN BROWSER
IRAK1-001
IRAK1-002
IRAK1-003
IRAK1-005
IRAK1-010
IRAK1-012
IRAK1-016
IRAK1-017
IRAK1-020

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IRAK1-001
ENSP00000358991
ENST00000369974
P51617 [Direct mapping]
Interleukin-1 receptor-associated kinase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0001959 [regulation of cytokine-mediated signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004704 [NF-kappaB-inducing kinase activity]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005811 [lipid particle]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007178 [transmembrane receptor protein serine/threonine kinase signaling pathway]
GO:0007250 [activation of NF-kappaB-inducing kinase activity]
GO:0007254 [JNK cascade]
GO:0010008 [endosome membrane]
GO:0016301 [kinase activity]
GO:0016567 [protein ubiquitination]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032481 [positive regulation of type I interferon production]
GO:0032496 [response to lipopolysaccharide]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035556 [intracellular signal transduction]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0045087 [innate immune response]
GO:0045323 [interleukin-1 receptor complex]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046777 [protein autophosphorylation]
GO:0046982 [protein heterodimerization activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051259 [protein oligomerization]
GO:0051403 [stress-activated MAPK cascade]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
GO:0070498 [interleukin-1-mediated signaling pathway]
GO:0070555 [response to interleukin-1]
Show all
 633 aa
68 kDa 		No 0
IRAK1-002
ENSP00000377291
ENST00000393687
P51617 [Direct mapping]
Interleukin-1 receptor-associated kinase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0001959 [regulation of cytokine-mediated signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004704 [NF-kappaB-inducing kinase activity]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005811 [lipid particle]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007178 [transmembrane receptor protein serine/threonine kinase signaling pathway]
GO:0007250 [activation of NF-kappaB-inducing kinase activity]
GO:0007254 [JNK cascade]
GO:0010008 [endosome membrane]
GO:0016301 [kinase activity]
GO:0016567 [protein ubiquitination]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032481 [positive regulation of type I interferon production]
GO:0032496 [response to lipopolysaccharide]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035556 [intracellular signal transduction]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0045087 [innate immune response]
GO:0045323 [interleukin-1 receptor complex]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046777 [protein autophosphorylation]
GO:0046982 [protein heterodimerization activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051259 [protein oligomerization]
GO:0051403 [stress-activated MAPK cascade]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
GO:0070498 [interleukin-1-mediated signaling pathway]
GO:0070555 [response to interleukin-1]
Show all
 682 aa
73.4 kDa 		No 0
IRAK1-003
ENSP00000406249
ENST00000437278
H7C2I6 [Direct mapping]
Interleukin-1 receptor-associated kinase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035556 [intracellular signal transduction]
GO:0043406 [positive regulation of MAP kinase activity]
Show all
 276 aa
28.9 kDa 		No 0
IRAK1-005
ENSP00000403730
ENST00000443220
H7C224 [Direct mapping]
Interleukin-1 receptor-associated kinase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035556 [intracellular signal transduction]
GO:0043406 [positive regulation of MAP kinase activity]
Show all
 392 aa
42.1 kDa 		No 0
IRAK1-010
ENSP00000410953
ENST00000444254
H7C3C1 [Direct mapping]
Interleukin-1 receptor-associated kinase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035556 [intracellular signal transduction]
GO:0043406 [positive regulation of MAP kinase activity]
Show all
 218 aa
22.6 kDa 		No 0
IRAK1-012
ENSP00000358997
ENST00000369980
P51617 [Direct mapping]
Interleukin-1 receptor-associated kinase 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0001959 [regulation of cytokine-mediated signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004704 [NF-kappaB-inducing kinase activity]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005149 [interleukin-1 receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005811 [lipid particle]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007178 [transmembrane receptor protein serine/threonine kinase signaling pathway]
GO:0007250 [activation of NF-kappaB-inducing kinase activity]
GO:0007254 [JNK cascade]
GO:0007568 [aging]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0016301 [kinase activity]
GO:0016567 [protein ubiquitination]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031072 [heat shock protein binding]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032481 [positive regulation of type I interferon production]
GO:0032494 [response to peptidoglycan]
GO:0032496 [response to lipopolysaccharide]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0034605 [cellular response to heat]
GO:0035556 [intracellular signal transduction]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0045087 [innate immune response]
GO:0045323 [interleukin-1 receptor complex]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046777 [protein autophosphorylation]
GO:0046982 [protein heterodimerization activity]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051259 [protein oligomerization]
GO:0051403 [stress-activated MAPK cascade]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
GO:0070498 [interleukin-1-mediated signaling pathway]
GO:0070555 [response to interleukin-1]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071456 [cellular response to hypoxia]
Show all
 712 aa
76.5 kDa 		No 0
IRAK1-016
ENSP00000411809
ENST00000455690
H7C3G8 [Direct mapping]
Interleukin-1 receptor-associated kinase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035556 [intracellular signal transduction]
GO:0043406 [positive regulation of MAP kinase activity]
Show all
 212 aa
23.5 kDa 		No 0
IRAK1-017
ENSP00000399974
ENST00000444230
H7C1F0 [Direct mapping]
Interleukin-1 receptor-associated kinase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035556 [intracellular signal transduction]
GO:0043406 [positive regulation of MAP kinase activity]
Show all
 234 aa
25.3 kDa 		No 0
IRAK1-020
ENSP00000392662
ENST00000429936
D3YTB5 [Direct mapping]
Interleukin-1 receptor-associated kinase 1
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035556 [intracellular signal transduction]
GO:0043406 [positive regulation of MAP kinase activity]
Show all
 708 aa
76.1 kDa 		No 0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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