Expression of ACOT1 in cancer - Summary - The Human Protein Atlas

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ACOT1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ACOT1
Gene description	Acyl-CoA thioesterase 1
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (T-47d)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several different tissue types, including renal tubules.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Approved based on 1 antibody. HPA043705
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA043705

GENE INFORMATION
Gene name	ACOT1 (HGNC Symbol)
Synonyms	ACH2, CTE-1, LACH2
Description	Acyl-CoA thioesterase 1 (HGNC Symbol)
Entrez gene summary
Chromosome	14
Cytoband	q24.3
Chromosome location (bp)	73537114 - 73543794
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000184227 (version 83.38)
Entrez gene	641371
UniProt	Q86TX2 (UniProt - Evidence at protein level)
neXtProt	NX_Q86TX2
Antibodypedia	ACOT1 antibodies

PROTEIN BROWSER

ACOT1-001	ACOT1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ACOT1-001 ENSP00000311224 ENST00000311148	Q86TX2 [Direct mapping] Acyl-coenzyme A thioesterase 1 E9KL42 [Target identity:100%; Query identity:100%] Epididymis secretory sperm binding protein Li 188n Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000038 [very long-chain fatty acid metabolic process] GO:0001676 [long-chain fatty acid metabolic process] GO:0005829 [cytosol] GO:0006637 [acyl-CoA metabolic process] GO:0016290 [palmitoyl-CoA hydrolase activity] GO:0016790 [thiolester hydrolase activity] GO:0019432 [triglyceride biosynthetic process] GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0047617 [acyl-CoA hydrolase activity] GO:0052689 [carboxylic ester hydrolase activity] Show all	421 aa 46.3 kDa	No	0
ACOT1-002 ENSP00000451764 ENST00000557556	G3V4F2 [Direct mapping] Acyl-coenzyme A thioesterase 1 Show all	SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006637 [acyl-CoA metabolic process] GO:0016790 [thiolester hydrolase activity] Show all	395 aa 43.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.