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ALDH1A3

GENERAL INFORMATION

Gene name

 ALDH1A3

Gene description

 Aldehyde dehydrogenase 1 family, member A3

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (melanoma, prostate cancer)
HPA (cell line):Cell line enhanced (A-431, HaCaT, U-2197, U-87 MG, WM-115)
HPA (normal tissue):Tissue enhanced (prostate)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several different tissue types including prostate.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA046271
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (melanoma, prostate cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA046271

GENE INFORMATION

Gene name

 ALDH1A3 (HGNC Symbol)

Synonyms

 ALDH6, RALDH3

Description

 Aldehyde dehydrogenase 1 family, member A3 (HGNC Symbol)

Entrez gene summary

 This gene encodes an aldehyde dehydrogenase enzyme that uses retinal as a substrate. Mutations in this gene have been associated with microphthalmia, isolated 8, and expression changes have also been detected in tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

Chromosome

 15

Cytoband

 q26.3

Chromosome location (bp)

 100877714 - 100916626

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000184254 (version 83.38)

Entrez gene

 220

UniProt

 P47895 (UniProt - Evidence at protein level)

neXtProt

 NX_P47895

Antibodypedia

 ALDH1A3 antibodies

PROTEIN BROWSER
ALDH1A3-001
ALDH1A3-004
ALDH1A3-006
ALDH1A3-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ALDH1A3-001
ENSP00000332256
ENST00000329841
P47895 [Direct mapping]
Aldehyde dehydrogenase family 1 member A3
A0A024RC95 [Target identity:100%; Query identity:100%]
Aldehyde dehydrogenase 1 family, member A3, isoform CRA_a
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Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001758 [retinal dehydrogenase activity]
GO:0002072 [optic cup morphogenesis involved in camera-type eye development]
GO:0002138 [retinoic acid biosynthetic process]
GO:0004029 [aldehyde dehydrogenase (NAD) activity]
GO:0004030 [aldehyde dehydrogenase [NAD(P)+] activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0007626 [locomotory behavior]
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0021768 [nucleus accumbens development]
GO:0031076 [embryonic camera-type eye development]
GO:0042472 [inner ear morphogenesis]
GO:0042572 [retinol metabolic process]
GO:0042573 [retinoic acid metabolic process]
GO:0042574 [retinal metabolic process]
GO:0042803 [protein homodimerization activity]
GO:0043065 [positive regulation of apoptotic process]
GO:0048048 [embryonic eye morphogenesis]
GO:0050885 [neuromuscular process controlling balance]
GO:0055114 [oxidation-reduction process]
GO:0060013 [righting reflex]
GO:0060166 [olfactory pit development]
GO:0060324 [face development]
GO:0070062 [extracellular exosome]
GO:0070324 [thyroid hormone binding]
GO:0070403 [NAD+ binding]
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 512 aa
56.1 kDa 		No 0
ALDH1A3-004
ENSP00000343294
ENST00000346623
H0Y2X5 [Direct mapping]
Aldehyde dehydrogenase 1 family, member A3, isoform CRA_b; Aldehyde dehydrogenase family 1 member A3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0001758 [retinal dehydrogenase activity]
GO:0004029 [aldehyde dehydrogenase (NAD) activity]
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
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 405 aa
44.3 kDa 		No 0
ALDH1A3-006
ENSP00000453328
ENST00000557963
H0YLT1 [Direct mapping]
Aldehyde dehydrogenase family 1 member A3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0001758 [retinal dehydrogenase activity]
GO:0004029 [aldehyde dehydrogenase (NAD) activity]
GO:0055114 [oxidation-reduction process]
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 102 aa
10.8 kDa 		No 0
ALDH1A3-007
ENSP00000452789
ENST00000561338
H0YKF9 [Direct mapping]
Aldehyde dehydrogenase family 1 member A3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0001758 [retinal dehydrogenase activity]
GO:0004029 [aldehyde dehydrogenase (NAD) activity]
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
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 145 aa
16.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.