Expression of DEFB108B in cancer - Summary - The Human Protein Atlas

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DEFB108B

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DEFB108B
Gene description	Defensin, beta 108B
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Not detected
HPA (normal tissue):	Not detected

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. No RNA expression data detected and pending external verification. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Uncertain based on 1 antibody. HPA042588
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA042588

GENE INFORMATION
Gene name	DEFB108B
Synonyms
Description	Defensin, beta 108B (HGNC Symbol)
Entrez gene summary	Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. A pseudogene of this gene has been found on chromosome 8. [provided by RefSeq, Oct 2014]
Chromosome	11
Cytoband	q13.4
Chromosome location (bp)	71833200 - 71837710
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000184276 (version 83.38)
Entrez gene	245911
UniProt	Q8NET1 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8NET1
Antibodypedia	DEFB108B antibodies

PROTEIN BROWSER

DEFB108B-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DEFB108B-001 ENSP00000333234 ENST00000328698	Q8NET1 [Direct mapping] Beta-defensin 108B Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005576 [extracellular region] GO:0009986 [cell surface] GO:0042742 [defense response to bacterium] GO:0045087 [innate immune response] Show all	73 aa 8.3 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.