Fields »
ABOUT
HELP
BLOG
SIX6

GENERAL INFORMATION

Gene name

 SIX6

Gene description

 SIX homeobox 6

Protein class

 Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (glioma)
HPA (cell line):Cell line enriched (MOLT-4)
HPA (normal tissue):Not detected

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in retina and pituitary gland.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Presumed off target binding observed and disregarded. External characterization data supports antibody staining but no internal RNA data available for correlation.

Reliability score

 Supported based on 1 antibody.
HPA001403
SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA001403

GENE INFORMATION

Gene name

 SIX6 (HGNC Symbol)

Synonyms

 OPTX2, Six9

Description

 SIX homeobox 6 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in eye development. Defects in this gene are a cause of isolated microphthalmia with cataract type 2 (MCOPCT2). [provided by RefSeq, Jul 2008]

Chromosome

 14

Cytoband

 q23.1

Chromosome location (bp)

 60508951 - 60512850

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000184302 (version 83.38)

Entrez gene

 4990

UniProt

 O95475 (UniProt - Evidence at protein level)

neXtProt

 NX_O95475

Antibodypedia

 SIX6 antibodies

PROTEIN BROWSER
SIX6-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SIX6-001
ENSP00000328596
ENST00000327720
O95475 [Direct mapping]
Homeobox protein SIX6
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001205 [transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007601 [visual perception]
GO:0009887 [organ morphogenesis]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 246 aa
27.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.