Fields »
ABOUT
HELP
BLOG
PRKD1

GENERAL INFORMATION

Gene name

 PRKD1

Gene description

 Protein kinase D1

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Tissue enhanced (parathyroid gland)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues at variable levels.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA029834 , CAB018367
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and thyroid cancer (unfavourable).
Renal cancer p<0.001
Thyroid cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA029834
CAB018367

GENE INFORMATION

Gene name

 PRKD1 (HGNC Symbol)

Synonyms

 PKC-mu, PKCM, PKD, PRKCM

Description

 Protein kinase D1 (HGNC Symbol)

Entrez gene summary

 PRKD1 is a serine/threonine kinase that regulates a variety of cellular functions, including membrane receptor signaling, transport at the Golgi, protection from oxidative stress at the mitochondria, gene transcription, and regulation of cell shape, motility, and adhesion (summary by Eiseler et al., 2009 [PubMed 19329994]).[supplied by OMIM, Nov 2010]

Chromosome

 14

Cytoband

 q12

Chromosome location (bp)

 29576479 - 30191898

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000184304 (version 83.38)

Entrez gene

 5587

UniProt

 Q15139 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15139

Antibodypedia

 PRKD1 antibodies

PROTEIN BROWSER
PRKD1-001
PRKD1-002
PRKD1-007
PRKD1-008
PRKD1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PRKD1-001
ENSP00000333568
ENST00000331968
Q15139 [Direct mapping]
Serine/threonine-protein kinase D1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004697 [protein kinase C activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005938 [cell cortex]
GO:0006468 [protein phosphorylation]
GO:0006665 [sphingolipid metabolic process]
GO:0006915 [apoptotic process]
GO:0006954 [inflammatory response]
GO:0007030 [Golgi organization]
GO:0007165 [signal transduction]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008283 [cell proliferation]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010837 [regulation of keratinocyte proliferation]
GO:0010976 [positive regulation of neuron projection development]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0030148 [sphingolipid biosynthetic process]
GO:0032793 [positive regulation of CREB transcription factor activity]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034599 [cellular response to oxidative stress]
GO:0035556 [intracellular signal transduction]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0038033 [positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway]
GO:0042802 [identical protein binding]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045766 [positive regulation of angiogenesis]
GO:0045806 [negative regulation of endocytosis]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048193 [Golgi vesicle transport]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051279 [regulation of release of sequestered calcium ion into cytosol]
GO:0060548 [negative regulation of cell death]
GO:0089700 [protein kinase D signaling]
GO:1901727 [positive regulation of histone deacetylase activity]
GO:2001028 [positive regulation of endothelial cell chemotaxis]
GO:2001044 [regulation of integrin-mediated signaling pathway]
Show all
 912 aa
101.7 kDa 		Yes 0
PRKD1-002
ENSP00000390535
ENST00000415220
F8WBA3 [Direct mapping]
Serine/threonine-protein kinase
Show all
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004697 [protein kinase C activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0035556 [intracellular signal transduction]
GO:0046872 [metal ion binding]
Show all
 920 aa
102.5 kDa 		Yes 0
PRKD1-007
ENSP00000447333
ENST00000546371
H0YHL5 [Direct mapping]
Serine/threonine-protein kinase D1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004697 [protein kinase C activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 157 aa
17.2 kDa 		No 0
PRKD1-008
ENSP00000446866
ENST00000549503
F8VZ98 [Direct mapping]
Serine/threonine-protein kinase D1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004697 [protein kinase C activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0035556 [intracellular signal transduction]
GO:0046872 [metal ion binding]
Show all
 117 aa
13.2 kDa 		No 0
PRKD1-201
ENSP00000482645
ENST00000616995
Q15139 [Direct mapping]
Serine/threonine-protein kinase D1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004697 [protein kinase C activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005802 [trans-Golgi network]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0006665 [sphingolipid metabolic process]
GO:0006915 [apoptotic process]
GO:0006954 [inflammatory response]
GO:0007030 [Golgi organization]
GO:0007165 [signal transduction]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008283 [cell proliferation]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0010837 [regulation of keratinocyte proliferation]
GO:0010976 [positive regulation of neuron projection development]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0030148 [sphingolipid biosynthetic process]
GO:0032793 [positive regulation of CREB transcription factor activity]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0034599 [cellular response to oxidative stress]
GO:0035556 [intracellular signal transduction]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0038033 [positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway]
GO:0042802 [identical protein binding]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0044281 [small molecule metabolic process]
GO:0045087 [innate immune response]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045766 [positive regulation of angiogenesis]
GO:0045806 [negative regulation of endocytosis]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048193 [Golgi vesicle transport]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0060548 [negative regulation of cell death]
GO:0089700 [protein kinase D signaling]
GO:1901727 [positive regulation of histone deacetylase activity]
GO:2001028 [positive regulation of endothelial cell chemotaxis]
GO:2001044 [regulation of integrin-mediated signaling pathway]
Show all
 912 aa
101.7 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.