Fields »
ABOUT
HELP
BLOG
HIST1H1B

GENERAL INFORMATION

Gene name

 HIST1H1B

Gene description

 Histone cluster 1, H1b

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (colorectal cancer)
HPA (cell line):Cell line enhanced (MOLT-4)
HPA (normal tissue):Tissue enhanced (bone marrow, lymph node)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining not consistent with RNA expression data. Caution, targets protein from more than one gene. External characterization data supports antibody staining.

Reliability score

 Uncertain based on 2 antibodies.
HPA055907 , CAB012241
SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (colorectal cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA055907
CAB012241

GENE INFORMATION

Gene name

 HIST1H1B (HGNC Symbol)

Synonyms

 H1.5, H1b, H1F5, H1s-3

Description

 Histone cluster 1, H1b (HGNC Symbol)

Entrez gene summary

 Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]

Chromosome

 6

Cytoband

 p22.1

Chromosome location (bp)

 27866849 - 27867529

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000184357 (version 83.38)

Entrez gene

 3009

UniProt

 P16401 (UniProt - Evidence at protein level)

neXtProt

 NX_P16401

Antibodypedia

 HIST1H1B antibodies

PROTEIN BROWSER
HIST1H1B-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HIST1H1B-001
ENSP00000330074
ENST00000331442
P16401 [Direct mapping]
Histone H1.5
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000786 [nucleosome]
GO:0000790 [nuclear chromatin]
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005720 [nuclear heterochromatin]
GO:0006325 [chromatin organization]
GO:0006334 [nucleosome assembly]
GO:0030307 [positive regulation of cell growth]
GO:0031490 [chromatin DNA binding]
GO:0042826 [histone deacetylase binding]
GO:0044822 [poly(A) RNA binding]
GO:0050821 [protein stabilization]
GO:0051574 [positive regulation of histone H3-K9 methylation]
GO:0070062 [extracellular exosome]
GO:0071169 [establishment of protein localization to chromatin]
Show all
 226 aa
22.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.