Expression of ACTRT3 in cancer - Summary - The Human Protein Atlas

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ACTRT3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ACTRT3
Gene description	Actin-related protein T3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Mixed
HPA (normal tissue):	Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Expression in testis.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 2 antibodies. HPA035817 , HPA035818
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable).
Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA035817	HPA035818

GENE INFORMATION
Gene name	ACTRT3 (HGNC Symbol)
Synonyms	ARPM1
Description	Actin-related protein T3 (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	q26.2
Chromosome location (bp)	169766921 - 169769895
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000184378 (version 83.38)
Entrez gene	84517
UniProt	Q9BYD9 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9BYD9
Antibodypedia	ACTRT3 antibodies

PROTEIN BROWSER

ACTRT3-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ACTRT3-001 ENSP00000333037 ENST00000330368	Q9BYD9 [Direct mapping] Actin-related protein T3 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0001673 [male germ cell nucleus] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] Show all	372 aa 41 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.