Cell atlas - PLA2G6 - The Human Protein Atlas

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PLA2G6

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Microtubule organizing center

Human cell
	Centrosome
	Cytosol

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GENERAL INFORMATION
Gene name	PLA2G6
Gene description	Phospholipase A2, group VI (cytosolic, calcium-independent)
Protein class	Disease related genes Enzymes FDA approved drug targets Predicted intracellular proteins Predicted membrane proteins RAS pathway related proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	15
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol & microtubule organizing center.
RNA cell category	Cell line enhanced (HEL)
Protein evidence	Evidence at protein level
Main location	Localized to the Microtubule organizing center (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA001171
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HEL) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol & microtubule organizing center.

Main location

Microtubule organizing center (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA001171	A-431	Microtubule organizing center
	HPA001171	U-2 OS	Microtubule organizing center
	HPA001171	U-2 OS	Cytosol
	HPA001171	U-251 MG	Cytosol

GENE INFORMATION
Gene name	PLA2G6 (HGNC Symbol)
Synonyms	iPLA2, iPLA2beta, NBIA2, PARK14, PNPLA9
Description	Phospholipase A2, group VI (cytosolic, calcium-independent) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only three of them have been determined to date. [provided by RefSeq, Dec 2010]
Chromosome	22
Cytoband	q13.1
Chromosome location (bp)	38111495 - 38205690
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000184381 (version 83.38)
Entrez gene	8398
UniProt	O60733 (UniProt - Evidence at protein level)
neXtProt	NX_O60733
Antibodypedia	PLA2G6 antibodies

PROTEIN BROWSER

PLA2G6-001	PLA2G6-002	PLA2G6-003	PLA2G6-005	PLA2G6-007	PLA2G6-010	PLA2G6-012	PLA2G6-014	PLA2G6-015	PLA2G6-016	PLA2G6-017	PLA2G6-018	PLA2G6-019	PLA2G6-027	PLA2G6-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PLA2G6-001 ENSP00000333142 ENST00000332509	O60733 [Direct mapping] 85/88 kDa calcium-independent phospholipase A2 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM RAS pathway related proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001934 [positive regulation of protein phosphorylation] GO:0004623 [phospholipase A2 activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005815 [microtubule organizing center] GO:0005829 [cytosol] GO:0006629 [lipid metabolic process] GO:0006644 [phospholipid metabolic process] GO:0006935 [chemotaxis] GO:0007204 [positive regulation of cytosolic calcium ion concentration] GO:0007613 [memory] GO:0008152 [metabolic process] GO:0014832 [urinary bladder smooth muscle contraction] GO:0016020 [membrane] GO:0016042 [lipid catabolic process] GO:0019731 [antibacterial humoral response] GO:0019901 [protein kinase binding] GO:0032049 [cardiolipin biosynthetic process] GO:0034976 [response to endoplasmic reticulum stress] GO:0035774 [positive regulation of insulin secretion involved in cellular response to glucose stimulus] GO:0035965 [cardiolipin acyl-chain remodeling] GO:0036151 [phosphatidylcholine acyl-chain remodeling] GO:0036152 [phosphatidylethanolamine acyl-chain remodeling] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0043008 [ATP-dependent protein binding] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0045909 [positive regulation of vasodilation] GO:0045921 [positive regulation of exocytosis] GO:0046474 [glycerophospholipid biosynthetic process] GO:0047499 [calcium-independent phospholipase A2 activity] GO:0051967 [negative regulation of synaptic transmission, glutamatergic] GO:0060135 [maternal process involved in female pregnancy] GO:0090037 [positive regulation of protein kinase C signaling] GO:0090200 [positive regulation of release of cytochrome c from mitochondria] GO:0090238 [positive regulation of arachidonic acid secretion] GO:1901339 [regulation of store-operated calcium channel activity] GO:2000304 [positive regulation of ceramide biosynthetic process] Show all	806 aa 89.9 kDa	No	1
PLA2G6-002 ENSP00000386100 ENST00000402064	O60733 [Direct mapping] 85/88 kDa calcium-independent phospholipase A2 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM RAS pathway related proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004623 [phospholipase A2 activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005815 [microtubule organizing center] GO:0005829 [cytosol] GO:0006629 [lipid metabolic process] GO:0006644 [phospholipid metabolic process] GO:0006935 [chemotaxis] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016042 [lipid catabolic process] GO:0019731 [antibacterial humoral response] GO:0032049 [cardiolipin biosynthetic process] GO:0035965 [cardiolipin acyl-chain remodeling] GO:0036151 [phosphatidylcholine acyl-chain remodeling] GO:0036152 [phosphatidylethanolamine acyl-chain remodeling] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0046474 [glycerophospholipid biosynthetic process] Show all	752 aa 84.1 kDa	No	1
PLA2G6-003 ENSP00000413597 ENST00000435484	F2Z3G2 [Direct mapping] 85/88 kDa calcium-independent phospholipase A2 Show all	MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all		99 aa 11.1 kDa	No	0
PLA2G6-005 ENSP00000404974 ENST00000417303	F2Z3G2 [Direct mapping] 85/88 kDa calcium-independent phospholipase A2 Show all	MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all		99 aa 11.1 kDa	No	0
PLA2G6-007 ENSP00000393761 ENST00000455341	F8WEQ9 [Direct mapping] 85/88 kDa calcium-independent phospholipase A2 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all		80 aa 9.2 kDa	No	0
PLA2G6-010 ENSP00000393361 ENST00000447598	F2Z3G2 [Direct mapping] 85/88 kDa calcium-independent phospholipase A2 Show all	MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all		99 aa 11.1 kDa	No	0
PLA2G6-012 ENSP00000401242 ENST00000436218	F8WEN3 [Direct mapping] 85/88 kDa calcium-independent phospholipase A2 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all		151 aa 17.4 kDa	No	0
PLA2G6-014 ENSP00000395464 ENST00000430886	B0QYE9 [Direct mapping] 85/88 kDa calcium-independent phospholipase A2 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	166 aa 18.6 kDa	No	0
PLA2G6-015 ENSP00000472058 ENST00000498338	M0R1Q9 [Direct mapping] 85/88 kDa calcium-independent phospholipase A2 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	120 aa 13.2 kDa	No	0
PLA2G6-016 ENSP00000407743 ENST00000427114	H0Y6T3 [Direct mapping] 85/88 kDa calcium-independent phospholipase A2 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	229 aa 25 kDa	No	0
PLA2G6-017 ENSP00000412629 ENST00000452542	H0Y7G5 [Direct mapping] 85/88 kDa calcium-independent phospholipase A2 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	197 aa 21.4 kDa	No	0
PLA2G6-018 ENSP00000408298 ENST00000427453	H0Y6W2 [Direct mapping] 85/88 kDa calcium-independent phospholipase A2 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	157 aa 17.2 kDa	No	0
PLA2G6-019 ENSP00000392968 ENST00000452794	H0Y4M7 [Direct mapping] 85/88 kDa calcium-independent phospholipase A2 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	124 aa 13.1 kDa	No	0
PLA2G6-027 ENSP00000473160 ENST00000594306	M0R3D9 [Direct mapping] 85/88 kDa calcium-independent phospholipase A2 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all		51 aa 5.8 kDa	No	0
PLA2G6-201 ENSP00000335149 ENST00000335539	O60733 [Direct mapping] 85/88 kDa calcium-independent phospholipase A2 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM RAS pathway related proteins Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004623 [phospholipase A2 activity] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005815 [microtubule organizing center] GO:0005829 [cytosol] GO:0006629 [lipid metabolic process] GO:0006644 [phospholipid metabolic process] GO:0006935 [chemotaxis] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016042 [lipid catabolic process] GO:0019731 [antibacterial humoral response] GO:0032049 [cardiolipin biosynthetic process] GO:0035965 [cardiolipin acyl-chain remodeling] GO:0036151 [phosphatidylcholine acyl-chain remodeling] GO:0036152 [phosphatidylethanolamine acyl-chain remodeling] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0046474 [glycerophospholipid biosynthetic process] Show all	752 aa 84.1 kDa	No	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.