Cell atlas - MAML2 - The Human Protein Atlas

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MAML2

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nuclear bodies
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	MAML2
Gene description	Mastermind-like transcriptional coactivator 2
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nuclear bodies. In addition localized to the cytosol & nucleoplasm.
RNA cell category	Cell line enhanced (HDLM-2)
Protein evidence	Evidence at protein level
Main location	Localized to the Nuclear bodies (supported)
Additional location	In addition localized to the Nucleoplasm (supported), Cytosol (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA035223
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HDLM-2) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nuclear bodies. In addition localized to the cytosol & nucleoplasm.

Main location

Nuclear bodies (supported)

Additional location

Nucleoplasm (supported), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA035223	A-431	Nuclear bodies	Intensity
	HPA035223	A-431	Cytosol
	HPA035223	U-2 OS	Nucleoplasm
	HPA035223	U-2 OS	Cytosol
	HPA035223	U-251 MG	Nucleoplasm
			Nuclear bodies
			Cytosol

GENE INFORMATION
Gene name	MAML2 (HGNC Symbol)
Synonyms	KIAA1819, MAM3
Description	Mastermind-like transcriptional coactivator 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the Mastermind-like family of proteins. All family members are proline and glutamine-rich, and contain a conserved basic domain that binds the ankyrin repeat domain of the intracellular domain of the Notch receptors (ICN1-4) in their N-terminus, and a transcriptional activation domain in their C-terminus. This protein binds to an extended groove that is formed by the interaction of CBF1, Suppressor of Hairless, LAG-1 (CSL) with ICN, and positively regulates Notch signaling. High levels of expression of this gene have been observed in several B cell-derived lymphomas. Translocations resulting in fusion proteins with both CRTC1 and CRTC3 have been implicated in the development of mucoepidermoid carcinomas, while a translocation event with CXCR4 has been linked with chronic lymphocytic leukemia (CLL). Copy number variation in the polyglutamine tract has been observed. [provided by RefSeq, Jan 2015]
Chromosome	11
Cytoband	q21
Chromosome location (bp)	95976598 - 96343180
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000184384 (version 83.38)
Entrez gene	84441
UniProt	Q8IZL2 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IZL2
Antibodypedia	MAML2 antibodies

PROTEIN BROWSER

MAML2-001	MAML2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MAML2-001 ENSP00000434552 ENST00000524717	Q8IZL2 [Direct mapping] Mastermind-like protein 2 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003713 [transcription coactivator activity] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005794 [Golgi apparatus] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007219 [Notch signaling pathway] GO:0010467 [gene expression] GO:0016607 [nuclear speck] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	1156 aa 125.2 kDa	No	0
MAML2-201 ENSP00000483371 ENST00000618849	A0A087X0G5 [Direct mapping] Mastermind-like protein 2 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		986 aa 108 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.