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KCND2

GENERAL INFORMATION

Gene name

 KCND2

Gene description

 Potassium channel, voltage gated Shal related subfamily D, member 2

Protein class

 Disease related genes
FDA approved drug targets
Predicted intracellular proteins
Predicted membrane proteins
Transporters
Voltage-gated ion channels

Predicted localization

 Intracellular,Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (glioma)
HPA (cell line):Cell line enhanced (ASC TERT1, SCLC-21H)
HPA (normal tissue):Tissue enhanced (cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression mainly in brain.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Presumed off target binding observed and disregarded. External characterization data supports antibody staining.

Reliability score

 Approved based on 1 antibody.
HPA029068
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (glioma)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA029068

GENE INFORMATION

Gene name

 KCND2 (HGNC Symbol)

Synonyms

 KIAA1044, Kv4.2, RK5

Description

 Potassium channel, voltage gated Shal related subfamily D, member 2 (HGNC Symbol)

Entrez gene summary

 Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member mediates a rapidly inactivating, A-type outward potassium current which is not under the control of the N terminus as it is in Shaker channels. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 q31.31

Chromosome location (bp)

 120273668 - 120750331

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000184408 (version 83.38)

Entrez gene

 3751

UniProt

 Q9NZV8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NZV8

Antibodypedia

 KCND2 antibodies

PROTEIN BROWSER
KCND2-001
KCND2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KCND2-001
ENSP00000333496
ENST00000331113
Q9NZV8 [Direct mapping]
Potassium voltage-gated channel subfamily D member 2
A4D0V9 [Target identity:100%; Query identity:100%]
Potassium voltage-gated channel, Shal-related subfamily, member 2
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Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Voltage-Gated Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
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GO:0001508 [action potential]
GO:0005216 [ion channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005250 [A-type (transient outward) potassium channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0007268 [synaptic transmission]
GO:0008076 [voltage-gated potassium channel complex]
GO:0016020 [membrane]
GO:0019228 [neuronal action potential]
GO:0019233 [sensory perception of pain]
GO:0030054 [cell junction]
GO:0030425 [dendrite]
GO:0031226 [intrinsic component of plasma membrane]
GO:0032809 [neuronal cell body membrane]
GO:0034765 [regulation of ion transmembrane transport]
GO:0043025 [neuronal cell body]
GO:0043197 [dendritic spine]
GO:0043204 [perikaryon]
GO:0044853 [plasma membrane raft]
GO:0045211 [postsynaptic membrane]
GO:0045475 [locomotor rhythm]
GO:0046872 [metal ion binding]
GO:0051260 [protein homooligomerization]
GO:0055085 [transmembrane transport]
GO:0071456 [cellular response to hypoxia]
GO:0071805 [potassium ion transmembrane transport]
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 630 aa
70.5 kDa 		Yes 6
KCND2-002
ENSP00000415463
ENST00000425288
H7C445 [Direct mapping]
Potassium voltage-gated channel subfamily D member 2
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Predicted intracellular proteins
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GO:0008076 [voltage-gated potassium channel complex]
GO:0071805 [potassium ion transmembrane transport]
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 177 aa
19.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.