We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
Predicted intracellular proteins Transcription factors Helix-turn-helix domains RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007050 [cell cycle arrest] GO:0007095 [mitotic G2 DNA damage checkpoint] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007517 [muscle organ development] GO:0008134 [transcription factor binding] GO:0008285 [negative regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009653 [anatomical structure morphogenesis] GO:0016525 [negative regulation of angiogenesis] GO:0019899 [enzyme binding] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0045087 [innate immune response] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048863 [stem cell differentiation] GO:0051151 [negative regulation of smooth muscle cell differentiation] GO:0070317 [negative regulation of G0 to G1 transition]
Predicted intracellular proteins Transcription factors Helix-turn-helix domains RAS pathway related proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007050 [cell cycle arrest] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007517 [muscle organ development] GO:0008134 [transcription factor binding] GO:0008285 [negative regulation of cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0009653 [anatomical structure morphogenesis] GO:0016525 [negative regulation of angiogenesis] GO:0019899 [enzyme binding] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0045087 [innate immune response] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048863 [stem cell differentiation] GO:0051151 [negative regulation of smooth muscle cell differentiation] GO:0070317 [negative regulation of G0 to G1 transition]