Fields »
ABOUT
HELP
BLOG
POU3F2

GENERAL INFORMATION

Gene name

 POU3F2

Gene description

 POU class 3 homeobox 2

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (glioma)
HPA (cell line):Cell line enhanced (AF22, U-251 MG, WM-115)
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 POU3F2 (HGNC Symbol)

Synonyms

 BRN2, OCT7, OTF7, POUF3

Description

 POU class 3 homeobox 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the POU-III class of neural transcription factors. The encoded protein is involved in neuronal differentiation and enhances the activation of corticotropin-releasing hormone regulated genes. Overexpression of this protein is associated with an increase in the proliferation of melanoma cells. [provided by RefSeq, Mar 2012]

Chromosome

 6

Cytoband

 q16.1

Chromosome location (bp)

 98834592 - 98839490

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000184486 (version 83.38)

Entrez gene

 5454

UniProt

 P20265 (UniProt - Evidence at protein level)

neXtProt

 NX_P20265

Antibodypedia

 POU3F2 antibodies

PROTEIN BROWSER
POU3F2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
POU3F2-001
ENSP00000329170
ENST00000328345
P20265 [Direct mapping]
POU domain, class 3, transcription factor 2
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001105 [RNA polymerase II transcription coactivator activity]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007420 [brain development]
GO:0008284 [positive regulation of cell proliferation]
GO:0008544 [epidermis development]
GO:0010629 [negative regulation of gene expression]
GO:0014002 [astrocyte development]
GO:0014044 [Schwann cell development]
GO:0021799 [cerebral cortex radially oriented cell migration]
GO:0021869 [forebrain ventricular zone progenitor cell division]
GO:0021979 [hypothalamus cell differentiation]
GO:0021985 [neurohypophysis development]
GO:0022011 [myelination in peripheral nervous system]
GO:0030182 [neuron differentiation]
GO:0040018 [positive regulation of multicellular organism growth]
GO:0042802 [identical protein binding]
GO:0043565 [sequence-specific DNA binding]
GO:0045595 [regulation of cell differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050770 [regulation of axonogenesis]
GO:0071310 [cellular response to organic substance]
Show all
 443 aa
46.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.