Expression of HDDC3 in cancer - Summary - The Human Protein Atlas

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HDDC3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	HDDC3
Gene description	HD domain containing 3
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic and nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Approved based on 1 antibody. HPA040895
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA040895

GENE INFORMATION
Gene name	HDDC3 (HGNC Symbol)
Synonyms	MGC45386
Description	HD domain containing 3 (HGNC Symbol)
Entrez gene summary
Chromosome	15
Cytoband	q26.1
Chromosome location (bp)	90929964 - 90932569
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000184508 (version 83.38)
Entrez gene	374659
UniProt	Q8N4P3 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N4P3
Antibodypedia	HDDC3 antibodies

PROTEIN BROWSER

HDDC3-001	HDDC3-002	HDDC3-004	HDDC3-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HDDC3-001 ENSP00000330721 ENST00000330334	Q8N4P3 [Direct mapping] Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0008728 [GTP diphosphokinase activity] GO:0008893 [guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity] GO:0015969 [guanosine tetraphosphate metabolic process] GO:0042594 [response to starvation] GO:0046872 [metal ion binding] Show all	140 aa 15.7 kDa	No	0
HDDC3-002 ENSP00000377814 ENST00000394272	Q8N4P3 [Direct mapping] Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0008728 [GTP diphosphokinase activity] GO:0008893 [guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity] GO:0015969 [guanosine tetraphosphate metabolic process] GO:0042594 [response to starvation] GO:0046872 [metal ion binding] Show all	179 aa 20.3 kDa	No	0
HDDC3-004 ENSP00000454103 ENST00000559898	H0YNP9 [Direct mapping] Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		143 aa 16 kDa	No	0
HDDC3-005 ENSP00000452937 ENST00000561036	H0YKT9 [Direct mapping] Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		152 aa 16.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.