Expression of BEX5 in cancer - Summary - The Human Protein Atlas

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BEX5

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	BEX5
Gene description	Brain expressed, X-linked 5
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (Karpas-707, SCLC-21H)
HPA (normal tissue):	Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly cytoplasmic and nucleoli expression in CNS.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA059058
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and lung cancer (favourable).
Renal cancer p<0.001 Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA059058

GENE INFORMATION
Gene name	BEX5 (HGNC Symbol)
Synonyms	NGFRAP1L1
Description	Brain expressed, X-linked 5 (HGNC Symbol)
Entrez gene summary
Chromosome	X
Cytoband	q22.1
Chromosome location (bp)	102153708 - 102156057
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000184515 (version 83.38)
Entrez gene	340542
UniProt	Q5H9J7 (UniProt - Evidence at protein level)
neXtProt	NX_Q5H9J7
Antibodypedia	BEX5 antibodies

PROTEIN BROWSER

BEX5-001	BEX5-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BEX5-001 ENSP00000328030 ENST00000333643	Q5H9J7 [Direct mapping] Protein BEX5 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0070062 [extracellular exosome] Show all	111 aa 12.6 kDa	No	0
BEX5-201 ENSP00000446054 ENST00000543160	Q5H9J7 [Direct mapping] Protein BEX5 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0070062 [extracellular exosome] Show all	111 aa 12.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.