Expression of LPAR5 in cancer - Summary - The Human Protein Atlas

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LPAR5

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LPAR5
Gene description	Lysophosphatidic acid receptor 5
Protein class	G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (HEL, HMC-1, K-562)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA013170
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PROGNOSTIC SUMMARY
Prognostic marker in thyroid cancer (favourable).
Thyroid cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA013170

GENE INFORMATION
Gene name	LPAR5 (HGNC Symbol)
Synonyms	GPR92, GPR93, KPG_010, LPA5
Description	Lysophosphatidic acid receptor 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the rhodopsin class of G protein-coupled transmembrane receptors. This protein transmits extracellular signals from lysophosphatidic acid to cells through heterotrimeric G proteins and mediates numerous cellular processes. Many G protein receptors serve as targets for pharmaceutical drugs. Transcript variants of this gene have been described.[provided by RefSeq, Dec 2008]
Chromosome	12
Cytoband	p13.31
Chromosome location (bp)	6618835 - 6636447
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000184574 (version 83.38)
Entrez gene	57121
UniProt	Q9H1C0 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9H1C0
Antibodypedia	LPAR5 antibodies

PROTEIN BROWSER

LPAR5-001	LPAR5-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LPAR5-001 ENSP00000327875 ENST00000329858	Q9H1C0 [Direct mapping] Lysophosphatidic acid receptor 5 Q5KU18 [Target identity:100%; Query identity:100%] G protein-coupled receptor 92, isoform CRA_a; G-protein coupled receptor; Lysophosphatidic acid receptor 5; cDNA, FLJ93614, Homo sapiens G protein-coupled receptor 92 (GPR92), mRNA Show all	G-protein coupled receptors GPCRs excl olfactory receptors Lysolipids receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0003674 [molecular_function] GO:0004930 [G-protein coupled receptor activity] GO:0005575 [cellular_component] GO:0005886 [plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0008150 [biological_process] GO:0016021 [integral component of membrane] Show all	372 aa 41.3 kDa	No	7
LPAR5-201 ENSP00000393098 ENST00000431922	Q9H1C0 [Direct mapping] Lysophosphatidic acid receptor 5 Q5KU18 [Target identity:100%; Query identity:100%] G protein-coupled receptor 92, isoform CRA_a; G-protein coupled receptor; Lysophosphatidic acid receptor 5; cDNA, FLJ93614, Homo sapiens G protein-coupled receptor 92 (GPR92), mRNA Show all	G-protein coupled receptors GPCRs excl olfactory receptors Lysolipids receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0003674 [molecular_function] GO:0004930 [G-protein coupled receptor activity] GO:0005575 [cellular_component] GO:0005886 [plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0008150 [biological_process] GO:0016021 [integral component of membrane] Show all	372 aa 41.3 kDa	No	7

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.