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Several pancreatic, prostatic, endometrial, colorectal, cervical cancers and melanomas showed moderate to strong cytoplasmic positivity. Other cancer tissues were negative.
Colorectal cancers and several cases of melanomas, ovarian, endometrial, stomach and pancreatic cancers displayed moderate to strong cytoplasmic positivity. Most of the remaining cancer cells were weakly stained or negative.
GENE INFORMATION
Gene name
TMEM173 (HGNC Symbol)
Synonyms
FLJ38577, NET23
Description
Transmembrane protein 173 (HGNC Symbol)
Entrez gene summary
This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]