Fields »
ABOUT
HELP
BLOG
PDE4B

GENERAL INFORMATION

Gene name

 PDE4B

Gene description

 Phosphodiesterase 4B, cAMP-specific

Protein class

 Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression with a granular pattern.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA003005
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Lung

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PDE4B (HGNC Symbol)

Synonyms

 DPDE4

Description

 Phosphodiesterase 4B, cAMP-specific (HGNC Symbol)

Entrez gene summary

 This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

Chromosome

 1

Cytoband

 p31.3

Chromosome location (bp)

 65792514 - 66374579

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000184588 (version 83.38)

Entrez gene

 5142

UniProt

 Q07343 (UniProt - Evidence at protein level)

neXtProt

 NX_Q07343

Antibodypedia

 PDE4B antibodies

PROTEIN BROWSER
PDE4B-001
PDE4B-002
PDE4B-003
PDE4B-006
PDE4B-007
PDE4B-008
PDE4B-009
PDE4B-010
PDE4B-011
PDE4B-014

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PDE4B-001
ENSP00000332116
ENST00000329654
Q07343 [Direct mapping]
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
X5DNX5 [Target identity:100%; Query identity:100%]
Phosphodiesterase 4B cAMP-specific isoform A
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0000930 [gamma-tubulin complex]
GO:0001780 [neutrophil homeostasis]
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0004115 [3',5'-cyclic-AMP phosphodiesterase activity]
GO:0005515 [protein binding]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006198 [cAMP catabolic process]
GO:0007165 [signal transduction]
GO:0008021 [synaptic vesicle]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0030018 [Z disc]
GO:0030552 [cAMP binding]
GO:0030593 [neutrophil chemotaxis]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032743 [positive regulation of interleukin-2 production]
GO:0035690 [cellular response to drug]
GO:0043015 [gamma-tubulin binding]
GO:0043197 [dendritic spine]
GO:0044325 [ion channel binding]
GO:0046872 [metal ion binding]
GO:0050852 [T cell receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0060076 [excitatory synapse]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071872 [cellular response to epinephrine stimulus]
GO:0071944 [cell periphery]
GO:0086004 [regulation of cardiac muscle cell contraction]
GO:1901841 [regulation of high voltage-gated calcium channel activity]
GO:1901898 [negative regulation of relaxation of cardiac muscle]
Show all
 736 aa
83.3 kDa 		No 0
PDE4B-002
ENSP00000342637
ENST00000341517
Q07343 [Direct mapping]
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
X5DNX5 [Target identity:100%; Query identity:100%]
Phosphodiesterase 4B cAMP-specific isoform A
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0001780 [neutrophil homeostasis]
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0004115 [3',5'-cyclic-AMP phosphodiesterase activity]
GO:0005829 [cytosol]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006198 [cAMP catabolic process]
GO:0007165 [signal transduction]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0030018 [Z disc]
GO:0030552 [cAMP binding]
GO:0030593 [neutrophil chemotaxis]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032743 [positive regulation of interleukin-2 production]
GO:0035690 [cellular response to drug]
GO:0044325 [ion channel binding]
GO:0046872 [metal ion binding]
GO:0050852 [T cell receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071872 [cellular response to epinephrine stimulus]
GO:0086004 [regulation of cardiac muscle cell contraction]
GO:1901841 [regulation of high voltage-gated calcium channel activity]
GO:1901898 [negative regulation of relaxation of cardiac muscle]
Show all
 736 aa
83.3 kDa 		No 0
PDE4B-003
ENSP00000392947
ENST00000423207
Q07343 [Direct mapping]
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0001780 [neutrophil homeostasis]
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0004115 [3',5'-cyclic-AMP phosphodiesterase activity]
GO:0005829 [cytosol]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006198 [cAMP catabolic process]
GO:0007165 [signal transduction]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0030018 [Z disc]
GO:0030552 [cAMP binding]
GO:0030593 [neutrophil chemotaxis]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032743 [positive regulation of interleukin-2 production]
GO:0035690 [cellular response to drug]
GO:0044325 [ion channel binding]
GO:0046872 [metal ion binding]
GO:0050852 [T cell receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071872 [cellular response to epinephrine stimulus]
GO:0086004 [regulation of cardiac muscle cell contraction]
GO:1901841 [regulation of high voltage-gated calcium channel activity]
GO:1901898 [negative regulation of relaxation of cardiac muscle]
Show all
 721 aa
82.1 kDa 		No 0
PDE4B-006
ENSP00000432400
ENST00000491340
H0YCV7 [Direct mapping]
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Show all
Predicted intracellular proteins
Show all
 66 aa
7.1 kDa 		No 0
PDE4B-007
ENSP00000360084
ENST00000371045
Q07343 [Direct mapping]
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Show all
GO:0001780 [neutrophil homeostasis]
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0004115 [3',5'-cyclic-AMP phosphodiesterase activity]
GO:0005829 [cytosol]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006198 [cAMP catabolic process]
GO:0007165 [signal transduction]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0030018 [Z disc]
GO:0030552 [cAMP binding]
GO:0030593 [neutrophil chemotaxis]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032743 [positive regulation of interleukin-2 production]
GO:0035690 [cellular response to drug]
GO:0044325 [ion channel binding]
GO:0046872 [metal ion binding]
GO:0050852 [T cell receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071872 [cellular response to epinephrine stimulus]
GO:0086004 [regulation of cardiac muscle cell contraction]
GO:1901841 [regulation of high voltage-gated calcium channel activity]
GO:1901898 [negative regulation of relaxation of cardiac muscle]
Show all
 564 aa
64.4 kDa 		No 0
PDE4B-008
ENSP00000432592
ENST00000480109
Q07343 [Direct mapping]
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
FDA approved drug targets
   Small molecule drugs
Show all
GO:0001780 [neutrophil homeostasis]
GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity]
GO:0004115 [3',5'-cyclic-AMP phosphodiesterase activity]
GO:0005829 [cytosol]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006198 [cAMP catabolic process]
GO:0007165 [signal transduction]
GO:0008081 [phosphoric diester hydrolase activity]
GO:0030018 [Z disc]
GO:0030552 [cAMP binding]
GO:0030593 [neutrophil chemotaxis]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032743 [positive regulation of interleukin-2 production]
GO:0035690 [cellular response to drug]
GO:0044325 [ion channel binding]
GO:0046872 [metal ion binding]
GO:0050852 [T cell receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071872 [cellular response to epinephrine stimulus]
GO:0086004 [regulation of cardiac muscle cell contraction]
GO:1901841 [regulation of high voltage-gated calcium channel activity]
GO:1901898 [negative regulation of relaxation of cardiac muscle]
Show all
 503 aa
57.7 kDa 		No 0
PDE4B-009
ENSP00000431909
ENST00000528771
E9PJ03 [Direct mapping]
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Show all
Predicted intracellular proteins
Show all
 137 aa
15.9 kDa 		No 0
PDE4B-010
ENSP00000437249
ENST00000531025
E9PNB0 [Direct mapping]
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Show all
Predicted intracellular proteins
Show all
 143 aa
16.6 kDa 		No 0
PDE4B-011
ENSP00000436104
ENST00000526197
E9PR34 [Direct mapping]
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Show all
Predicted intracellular proteins
Show all
 152 aa
17.6 kDa 		No 0
PDE4B-014
ENSP00000397548
ENST00000412480
E9PMG3 [Direct mapping]
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Show all
Predicted intracellular proteins
Show all
 147 aa
16.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.