Expression of DDX53 in cancer - Summary - The Human Protein Atlas

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DDX53

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	DDX53
Gene description	DEAD (Asp-Glu-Ala-Asp) box polypeptide 53
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (testis cancer)
HPA (cell line):	Cell line enhanced (K-562, RPMI-8226, U-2197, U-266/84)
HPA (normal tissue):	Tissue enriched (testis)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (testis cancer)

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	DDX53 (HGNC Symbol)
Synonyms	CAGE, CT26
Description	DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 (HGNC Symbol)
Entrez gene summary	This intronless gene encodes a protein which contains several domains found in members of the DEAD-box helicase protein family. Other members of this protein family participate in ATP-dependent RNA unwinding. [provided by RefSeq, Sep 2011]
Chromosome	X
Cytoband	p22.11
Chromosome location (bp)	22999961 - 23003589
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000184735 (version 83.38)
Entrez gene	168400
UniProt	Q86TM3 (UniProt - Evidence at protein level)
neXtProt	NX_Q86TM3
Antibodypedia	DDX53 antibodies

PROTEIN BROWSER

DDX53-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DDX53-001 ENSP00000368667 ENST00000327968	Q86TM3 [Direct mapping] Probable ATP-dependent RNA helicase DDX53 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0010501 [RNA secondary structure unwinding] Show all	631 aa 71.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.