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UBE2G2

GENERAL INFORMATION

Gene name

 UBE2G2

Gene description

 Ubiquitin-conjugating enzyme E2G 2

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA003332
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA003332

GENE INFORMATION

Gene name

 UBE2G2 (HGNC Symbol)

Synonyms

 UBC7

Description

 Ubiquitin-conjugating enzyme E2G 2 (HGNC Symbol)

Entrez gene summary

 The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse counterpart. This gene is ubiquitously expressed, with high expression seen in adult muscle. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

Chromosome

 21

Cytoband

 q22.3

Chromosome location (bp)

 44768580 - 44802019

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000184787 (version 83.38)

Entrez gene

 7327

UniProt

 P60604 (UniProt - Evidence at protein level)

neXtProt

 NX_P60604

Antibodypedia

 UBE2G2 antibodies

PROTEIN BROWSER
UBE2G2-001
UBE2G2-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
UBE2G2-001
ENSP00000338348
ENST00000345496
P60604 [Direct mapping]
Ubiquitin-conjugating enzyme E2 G2
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process]
GO:0031625 [ubiquitin protein ligase binding]
GO:0035458 [cellular response to interferon-beta]
GO:0042802 [identical protein binding]
GO:0044257 [cellular protein catabolic process]
GO:0061630 [ubiquitin protein ligase activity]
GO:0061631 [ubiquitin conjugating enzyme activity]
GO:0070936 [protein K48-linked ubiquitination]
GO:1904153 [negative regulation of retrograde protein transport, ER to cytosol]
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 165 aa
18.6 kDa 		No 0
UBE2G2-005
ENSP00000331384
ENST00000330942
P60604 [Direct mapping]
Ubiquitin-conjugating enzyme E2 G2
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process]
GO:0031625 [ubiquitin protein ligase binding]
GO:0035458 [cellular response to interferon-beta]
GO:0044257 [cellular protein catabolic process]
GO:0061630 [ubiquitin protein ligase activity]
GO:0061631 [ubiquitin conjugating enzyme activity]
GO:0070936 [protein K48-linked ubiquitination]
GO:1904153 [negative regulation of retrograde protein transport, ER to cytosol]
Show all
 137 aa
15.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.