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Most malignancies showed moderate staining. Several ovarian and colorectal cancers displayed strong positivity.
GENE INFORMATION
Gene name
OSBP2 (HGNC Symbol)
Synonyms
KIAA1664, ORP-4, ORP4, OSBPL1
Description
Oxysterol binding protein 2 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene contains a pleckstrin homology (PH) domain and an oxysterol-binding region. It binds oxysterols such as 7-ketocholesterol and may inhibit their cytotoxicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2013]