Expression of TUSC5 in cancer - Summary

GENERAL INFORMATION
Gene name	TUSC5
Gene description	Tumor suppressor candidate 5
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (breast cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (adipose tissue)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several different tissue, including adipose tissue and renal tubules.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA050825
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (breast cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA050825

GENE INFORMATION
Gene name	TUSC5 (HGNC Symbol)
Synonyms	IFITMD3, LOST1
Description	Tumor suppressor candidate 5 (HGNC Symbol)
Entrez gene summary
Chromosome	17
Cytoband	p13.3
Chromosome location (bp)	1279663 - 1300987
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000184811 (version 83.38)
Entrez gene	286753
UniProt	Q8IXB3 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8IXB3
Antibodypedia	TUSC5 antibodies

PROTEIN BROWSER

TUSC5-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TUSC5-001 ENSP00000329548 ENST00000333813	Q8IXB3 [Direct mapping] Tumor suppressor candidate 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0009607 [response to biotic stimulus] GO:0016021 [integral component of membrane] Show all	177 aa 19.3 kDa	No	2