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SRY

GENERAL INFORMATION

Gene name

 SRY

Gene description

 Sex determining region Y

Protein class

 Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (testis cancer)
HPA (cell line):Cell line enhanced (hTCEpi, RT4)
HPA (normal tissue):Tissue enhanced (skin, testis)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (testis cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 SRY (HGNC Symbol)

Synonyms

 TDF

Description

 Sex determining region Y (HGNC Symbol)

Entrez gene summary

 This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome); translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome. [provided by RefSeq, Jul 2008]

Chromosome

 Y

Cytoband

 p11.2

Chromosome location (bp)

 2786855 - 2787699

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000184895 (version 83.38)

Entrez gene

 6736

UniProt

 Q05066 (UniProt - Evidence at protein level)

neXtProt

 NX_Q05066

Antibodypedia

 SRY antibodies

PROTEIN BROWSER
SRY-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SRY-001
ENSP00000372547
ENST00000383070
Q05066 [Direct mapping]
Sex-determining region Y protein
A7WPU8 [Target identity:100%; Query identity:100%]
Sex-determining region Y protein
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Predicted intracellular proteins
Transcription factors
   Other all-alpha-helical DNA-binding domains
Disease related genes
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007530 [sex determination]
GO:0008134 [transcription factor binding]
GO:0008301 [DNA binding, bending]
GO:0008584 [male gonad development]
GO:0010629 [negative regulation of gene expression]
GO:0016607 [nuclear speck]
GO:0030154 [cell differentiation]
GO:0030238 [male sex determination]
GO:0044798 [nuclear transcription factor complex]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046982 [protein heterodimerization activity]
GO:2000020 [positive regulation of male gonad development]
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 204 aa
23.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.