Expression of MUC6 in cancer - Summary - The Human Protein Atlas

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MUC6

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MUC6
Gene description	Mucin 6, oligomeric mucus/gel-forming
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (stomach cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Group enriched (duodenum, seminal vesicle, stomach)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct cytoplasmic expression in stomach, seminal vesicle and gallbladder

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. CAB002165
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (stomach cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB002165

GENE INFORMATION
Gene name	MUC6
Synonyms
Description	Mucin 6, oligomeric mucus/gel-forming (HGNC Symbol)
Entrez gene summary	The MUC6 gene encodes gastric mucin, a secreted glycoprotein that plays an essential role in epithelial cytoprotection from acid, proteases, pathogenic microorganisms, and mechanical trauma in the gastrointestinal tract (summary by Toribara et al., 1993 [PubMed 7680650]).[supplied by OMIM, Dec 2010]
Chromosome	11
Cytoband	p15.5
Chromosome location (bp)	1012821 - 1036706
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000184956 (version 83.38)
Entrez gene	4588
UniProt	Q6W4X9 (UniProt - Evidence at protein level)
neXtProt	NX_Q6W4X9
Antibodypedia	MUC6 antibodies

PROTEIN BROWSER

MUC6-001	MUC6-002	MUC6-003	MUC6-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MUC6-001 ENSP00000406861 ENST00000421673	Q6W4X9 [Direct mapping] Mucin-6 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005201 [extracellular matrix structural constituent] GO:0005576 [extracellular region] GO:0005796 [Golgi lumen] GO:0006493 [protein O-linked glycosylation] GO:0016266 [O-glycan processing] GO:0030277 [maintenance of gastrointestinal epithelium] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	2439 aa 257 kDa	Yes	0
MUC6-002 ENSP00000433790 ENST00000525923	E9PJC5 [Direct mapping] Mucin-6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0030277 [maintenance of gastrointestinal epithelium] Show all	181 aa 19.3 kDa	No	0
MUC6-003 ENSP00000436903 ENST00000527242	H0YEZ6 [Direct mapping] Mucin-6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		115 aa 11.4 kDa	No	0
MUC6-004 ENSP00000433246 ENST00000532016	H0YDA7 [Direct mapping] Mucin-6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		219 aa 22.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.