Expression of CHRM5 in cancer - Summary - The Human Protein Atlas

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CHRM5

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CHRM5
Gene description	Cholinergic receptor, muscarinic 5
Protein class	FDA approved drug targets G-protein coupled receptors Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Group enriched (BEWO, HMC-1)
HPA (normal tissue):	Tissue enhanced (cerebral cortex, testis)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. Antibody staining not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA013172
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA013172

GENE INFORMATION
Gene name	CHRM5
Synonyms
Description	Cholinergic receptor, muscarinic 5 (HGNC Symbol)
Entrez gene summary	The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, stimulation of this receptor is known to increase cyclic AMP levels. [provided by RefSeq, Jul 2008]
Chromosome	15
Cytoband	q14
Chromosome location (bp)	33968720 - 34067457
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000184984 (version 83.38)
Entrez gene	1133
UniProt	P08912 (UniProt - Evidence at transcript level)
neXtProt	NX_P08912
Antibodypedia	CHRM5 antibodies

PROTEIN BROWSER

CHRM5-001	CHRM5-002	CHRM5-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CHRM5-001 ENSP00000372750 ENST00000383263	P08912 [Direct mapping] Muscarinic acetylcholine receptor M5 A0A024R9I2 [Target identity:100%; Query identity:100%] Muscarinic acetylcholine receptor Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0001696 [gastric acid secretion] GO:0004435 [phosphatidylinositol phospholipase C activity] GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007197 [adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway] GO:0007207 [phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway] GO:0007213 [G-protein coupled acetylcholine receptor signaling pathway] GO:0007271 [synaptic transmission, cholinergic] GO:0007606 [sensory perception of chemical stimulus] GO:0008283 [cell proliferation] GO:0015872 [dopamine transport] GO:0016021 [integral component of membrane] GO:0016907 [G-protein coupled acetylcholine receptor activity] GO:0019226 [transmission of nerve impulse] GO:0030054 [cell junction] GO:0045202 [synapse] GO:0045211 [postsynaptic membrane] GO:0060304 [regulation of phosphatidylinositol dephosphorylation] Show all	532 aa 60.1 kDa	No	7
CHRM5-002 ENSP00000453745 ENST00000557872	P08912 [Direct mapping] Muscarinic acetylcholine receptor M5 A0A024R9I2 [Target identity:100%; Query identity:100%] Muscarinic acetylcholine receptor Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0001696 [gastric acid secretion] GO:0004435 [phosphatidylinositol phospholipase C activity] GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007197 [adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway] GO:0007207 [phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway] GO:0007213 [G-protein coupled acetylcholine receptor signaling pathway] GO:0007271 [synaptic transmission, cholinergic] GO:0007606 [sensory perception of chemical stimulus] GO:0008283 [cell proliferation] GO:0016021 [integral component of membrane] GO:0030054 [cell junction] GO:0045202 [synapse] GO:0045211 [postsynaptic membrane] Show all	532 aa 60.1 kDa	No	7
CHRM5-003 ENSP00000452742 ENST00000560035	H0YKC0 [Direct mapping] Muscarinic acetylcholine receptor M5 Show all	Predicted intracellular proteins Show all	GO:0007207 [phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway] GO:0007271 [synaptic transmission, cholinergic] GO:0007606 [sensory perception of chemical stimulus] GO:0045202 [synapse] Show all	22 aa 2.4 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.