Expression of SORCS2 in cancer - Summary - The Human Protein Atlas

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SORCS2

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	SORCS2
Gene description	Sortilin-related VPS10 domain containing receptor 2
Protein class	Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (HaCaT, HMC-1, SiHa)
HPA (normal tissue):	Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and ovarian cancer (unfavourable).
Renal cancer p<0.001 Ovarian cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	SORCS2 (HGNC Symbol)
Synonyms	KIAA1329
Description	Sortilin-related VPS10 domain containing receptor 2 (HGNC Symbol)
Entrez gene summary	This gene encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing receptor proteins. The VPS10 domain name comes from the yeast carboxypeptidase Y sorting receptor Vps10 protein. Members of this gene family are large with many exons but the CDS lengths are usually less than 3700 nt. Very large introns typically separate the exons encoding the VPS10 domain; the remaining exons are separated by much smaller-sized introns. These genes are strongly expressed in the central nervous system. [provided by RefSeq, Jul 2008]
Chromosome	4
Cytoband	p16.1
Chromosome location (bp)	7192538 - 7742836
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000184985 (version 83.38)
Entrez gene	57537
UniProt	Q96PQ0 (UniProt - Evidence at protein level)
neXtProt	NX_Q96PQ0
Antibodypedia	SORCS2 antibodies

PROTEIN BROWSER

SORCS2-001	SORCS2-003	SORCS2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SORCS2-001 ENSP00000422185 ENST00000507866	Q96PQ0 [Direct mapping] VPS10 domain-containing receptor SorCS2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0007218 [neuropeptide signaling pathway] GO:0008188 [neuropeptide receptor activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	1159 aa 128.2 kDa	Yes	1
SORCS2-003 ENSP00000424194 ENST00000505529	H0Y9I2 [Direct mapping] VPS10 domain-containing receptor SorCS2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	101 aa 11.1 kDa	No	1
SORCS2-201 ENSP00000329124 ENST00000329016	B5MED8 [Direct mapping] VPS10 domain-containing receptor SorCS2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	987 aa 110.6 kDa	No	1

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.