Expression of BRI3BP in cancer - Summary - The Human Protein Atlas

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BRI3BP

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	BRI3BP
Gene description	BRI3 binding protein
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA014957
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA014957

GENE INFORMATION
Gene name	BRI3BP (HGNC Symbol)
Synonyms	BNAS1, HCCR-2, KG19
Description	BRI3 binding protein (HGNC Symbol)
Entrez gene summary
Chromosome	12
Cytoband	q24.31
Chromosome location (bp)	124993700 - 125031231
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000184992 (version 83.38)
Entrez gene	140707
UniProt	Q8WY22 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WY22
Antibodypedia	BRI3BP antibodies

PROTEIN BROWSER

BRI3BP-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BRI3BP-001 ENSP00000340761 ENST00000341446	Q8WY22 [Direct mapping] BRI3-binding protein Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0016021 [integral component of membrane] Show all	251 aa 27.8 kDa	Yes	3

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.