Expression of LRRC14B in cancer - Summary - The Human Protein Atlas

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LRRC14B

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LRRC14B
Gene description	Leucine rich repeat containing 14B
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (renal cancer)
HPA (cell line):	Cell line enhanced (REH, U-266/70, U-266/84)
HPA (normal tissue):	Group enriched (heart muscle, skeletal muscle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification. Presumed off target binding observed and disregarded.
Reliability score	Uncertain based on 2 antibodies. HPA038046 , HPA038047
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (renal cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA038046	HPA038047

GENE INFORMATION
Gene name	LRRC14B
Synonyms
Description	Leucine rich repeat containing 14B (HGNC Symbol)
Entrez gene summary
Chromosome	5
Cytoband	p15.33
Chromosome location (bp)	191511 - 195353
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185028 (version 83.38)
Entrez gene	389257
UniProt	A6NHZ5 (UniProt - Inferred from homology)
neXtProt	NX_A6NHZ5
Antibodypedia	LRRC14B antibodies

PROTEIN BROWSER

LRRC14B-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LRRC14B-001 ENSP00000327675 ENST00000328278	A6NHZ5 [Direct mapping] Leucine-rich repeat-containing protein 14B Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all		514 aa 56.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.