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Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

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Score

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Antibodies

Column

 
 
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CIB1
  • TISSUE

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  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

CIB1

Gene description

Calcium and integrin binding 1 (calmyrin)

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues, most abundant in endothelial cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

Approved based on 1 antibody.
CAB012991
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PROGNOSTIC SUMMARY

Prognostic marker in endometrial cancer (favourable).
Endometrial cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

CAB012991

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Several cases of endometrial cancer, head and neck cancers, along with few cases of hepatocellular carcinomas, duct carcinomas of breast, pancreas, prostate and urothelial cancers displayed moderate membranous and cytoplasmic staining. Several cases of squamous cell carcinomas of cervix showed weak to moderate cytoplasmic positivity. Remaining cancer tissues were weakly stained or negative.

GENE INFORMATION

Gene name

CIB1 (HGNC Symbol)

Synonyms

CALMYRIN, CIB, KIP, SIP2-28

Description

Calcium and integrin binding 1 (calmyrin) (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the EF-hand domain-containing calcium-binding superfamily. The encoded protein interacts with many other proteins, including the platelet integrin alpha-IIb-beta-3, DNA-dependent protein kinase, presenilin-2, focal adhesion kinase, p21 activated kinase, and protein kinase D. The encoded protein may be involved in cell survival and proliferation, and is associated with several disease states including cancer and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]

Chromosome

15

Cytoband

q26.1

Chromosome location (bp)

90229975 - 90234047

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000185043 (version 83.38)

Entrez gene

10519

UniProt

Q99828 (UniProt - Evidence at protein level)

neXtProt

NX_Q99828

Antibodypedia

CIB1 antibodies

PROTEIN BROWSER

CIB1-001
CIB1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CIB1-001
ENSP00000333873
ENST00000328649
Q99828 [Direct mapping]
Calcium and integrin-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001954 [positive regulation of cell-matrix adhesion]
GO:0002931 [response to ischemia]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005813 [centrosome]
GO:0005886 [plasma membrane]
GO:0006302 [double-strand break repair]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007026 [negative regulation of microtubule depolymerization]
GO:0007113 [endomitotic cell cycle]
GO:0007155 [cell adhesion]
GO:0007286 [spermatid development]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008427 [calcium-dependent protein kinase inhibitor activity]
GO:0010977 [negative regulation of neuron projection development]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0017016 [Ras GTPase binding]
GO:0030027 [lamellipodium]
GO:0030220 [platelet formation]
GO:0030291 [protein serine/threonine kinase inhibitor activity]
GO:0030307 [positive regulation of cell growth]
GO:0030335 [positive regulation of cell migration]
GO:0030426 [growth cone]
GO:0031122 [cytoplasmic microtubule organization]
GO:0031982 [vesicle]
GO:0032433 [filopodium tip]
GO:0032587 [ruffle membrane]
GO:0033630 [positive regulation of cell adhesion mediated by integrin]
GO:0038163 [thrombopoietin-mediated signaling pathway]
GO:0042127 [regulation of cell proliferation]
GO:0042383 [sarcolemma]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043066 [negative regulation of apoptotic process]
GO:0043495 [protein anchor]
GO:0045653 [negative regulation of megakaryocyte differentiation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048554 [positive regulation of metalloenzyme activity]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051301 [cell division]
GO:0051302 [regulation of cell division]
GO:0051898 [negative regulation of protein kinase B signaling]
GO:0070062 [extracellular exosome]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070886 [positive regulation of calcineurin-NFAT signaling cascade]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071901 [negative regulation of protein serine/threonine kinase activity]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0071944 [cell periphery]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis]
GO:0090314 [positive regulation of protein targeting to membrane]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
GO:1990090 [cellular response to nerve growth factor stimulus]
GO:2000256 [positive regulation of male germ cell proliferation]
Show all
191 aa
21.7 kDa
No 0
CIB1-201
ENSP00000479860
ENST00000612800
Q99828 [Direct mapping]
Calcium and integrin-binding protein 1
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001933 [negative regulation of protein phosphorylation]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0001954 [positive regulation of cell-matrix adhesion]
GO:0002931 [response to ischemia]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005813 [centrosome]
GO:0005886 [plasma membrane]
GO:0006302 [double-strand break repair]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007026 [negative regulation of microtubule depolymerization]
GO:0007113 [endomitotic cell cycle]
GO:0007155 [cell adhesion]
GO:0007286 [spermatid development]
GO:0008022 [protein C-terminus binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008427 [calcium-dependent protein kinase inhibitor activity]
GO:0010977 [negative regulation of neuron projection development]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0017016 [Ras GTPase binding]
GO:0019901 [protein kinase binding]
GO:0030027 [lamellipodium]
GO:0030220 [platelet formation]
GO:0030291 [protein serine/threonine kinase inhibitor activity]
GO:0030307 [positive regulation of cell growth]
GO:0030335 [positive regulation of cell migration]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0031122 [cytoplasmic microtubule organization]
GO:0031982 [vesicle]
GO:0032433 [filopodium tip]
GO:0032587 [ruffle membrane]
GO:0033630 [positive regulation of cell adhesion mediated by integrin]
GO:0038163 [thrombopoietin-mediated signaling pathway]
GO:0042127 [regulation of cell proliferation]
GO:0042383 [sarcolemma]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043066 [negative regulation of apoptotic process]
GO:0043495 [protein anchor]
GO:0044325 [ion channel binding]
GO:0045653 [negative regulation of megakaryocyte differentiation]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048554 [positive regulation of metalloenzyme activity]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051301 [cell division]
GO:0051302 [regulation of cell division]
GO:0051898 [negative regulation of protein kinase B signaling]
GO:0070062 [extracellular exosome]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070886 [positive regulation of calcineurin-NFAT signaling cascade]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071901 [negative regulation of protein serine/threonine kinase activity]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0071944 [cell periphery]
GO:0090004 [positive regulation of establishment of protein localization to plasma membrane]
GO:0090050 [positive regulation of cell migration involved in sprouting angiogenesis]
GO:0090314 [positive regulation of protein targeting to membrane]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:1904030 [negative regulation of cyclin-dependent protein kinase activity]
GO:1990090 [cellular response to nerve growth factor stimulus]
GO:2000256 [positive regulation of male germ cell proliferation]
Show all
231 aa
26 kDa
No 0

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