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A few colorectal, breast, endometrial, lung, pancreatic and liver cancers displayed weak to moderate cytoplasmic positivity. Remaining cancer cells were negative.
GENE INFORMATION
Gene name
INTS5 (HGNC Symbol)
Synonyms
INT5, KIAA1698
Description
Integrator complex subunit 5 (HGNC Symbol)
Entrez gene summary
INTS5 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]