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Interaction of Fas ligand (TNFSF6) with the FAS antigen (TNFRSF6) mediates programmed cell death, also called apoptosis, in a number of organ systems. The protein encoded by this gene binds to FAS antigen and can initiate apoptosis or enhance apoptosis initiated through FAS antigen. Initiation of apoptosis by the protein encoded by this gene requires a ubiquitin-like domain but not the FAS-binding domain. [provided by RefSeq, Jul 2008]
Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005635 [nuclear envelope] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006915 [apoptotic process] GO:0007253 [cytoplasmic sequestering of NF-kappaB] GO:0008219 [cell death] GO:0010942 [positive regulation of cell death] GO:0019887 [protein kinase regulator activity] GO:0019901 [protein kinase binding] GO:0019904 [protein domain specific binding] GO:0030155 [regulation of cell adhesion] GO:0031072 [heat shock protein binding] GO:0031265 [CD95 death-inducing signaling complex] GO:0031334 [positive regulation of protein complex assembly] GO:0031625 [ubiquitin protein ligase binding] GO:0034098 [VCP-NPL4-UFD1 AAA ATPase complex] GO:0042176 [regulation of protein catabolic process] GO:0043065 [positive regulation of apoptotic process] GO:0043130 [ubiquitin binding] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0045859 [regulation of protein kinase activity] GO:0048471 [perinuclear region of cytoplasm] GO:0051059 [NF-kappaB binding] GO:1902043 [positive regulation of extrinsic apoptotic signaling pathway via death domain receptors]