Expression of C6orf120 in cancer - Summary - The Human Protein Atlas

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C6orf120

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	C6orf120
Gene description	Chromosome 6 open reading frame 120
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA039626
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), cervical cancer (unfavourable) and ovarian cancer (unfavourable).
Liver cancer p<0.001 Cervical cancer p<0.001 Ovarian cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA039626

GENE INFORMATION
Gene name	C6orf120 (HGNC Symbol)
Synonyms	bA160E12.4
Description	Chromosome 6 open reading frame 120 (HGNC Symbol)
Entrez gene summary	This gene encodes a conserved, N-glycosylated protein that likely functions in the cellular response to endoplasmic reticulum stress. This protein is able to induce apoptosis in vitro in CD4+ T-cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]
Chromosome	6
Cytoband	q27
Chromosome location (bp)	169702190 - 169704856
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185127 (version 83.38)
Entrez gene	387263
UniProt	Q7Z4R8 (UniProt - Evidence at protein level)
neXtProt	NX_Q7Z4R8
Antibodypedia	C6orf120 antibodies

PROTEIN BROWSER

C6orf120-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
C6orf120-001 ENSP00000346931 ENST00000332290	Q7Z4R8 [Direct mapping] UPF0669 protein C6orf120 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0006915 [apoptotic process] GO:0070062 [extracellular exosome] Show all	191 aa 20.8 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.