Expression of NRBP2 in cancer - Summary - The Human Protein Atlas

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NRBP2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NRBP2
Gene description	Nuclear receptor binding protein 2
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression with additional nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA029052 , CAB020944
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

Endometrial cancer

STAINING SUMMARY

HPA029052	CAB020944

GENE INFORMATION
Gene name	NRBP2 (HGNC Symbol)
Synonyms	DKFZp434P086
Description	Nuclear receptor binding protein 2 (HGNC Symbol)
Entrez gene summary
Chromosome	8
Cytoband	q24.3
Chromosome location (bp)	143833594 - 143840974
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185189 (version 83.38)
Entrez gene	340371
UniProt	Q9NSY0 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9NSY0
Antibodypedia	NRBP2 antibodies

PROTEIN BROWSER

NRBP2-001	NRBP2-009	NRBP2-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NRBP2-001 ENSP00000414055 ENST00000442628	Q9NSY0 [Direct mapping] Nuclear receptor-binding protein 2 Show all	Enzymes Kinases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0016242 [negative regulation of macroautophagy] GO:0030182 [neuron differentiation] GO:0043524 [negative regulation of neuron apoptotic process] Show all	501 aa 57.8 kDa	No	0
NRBP2-009 ENSP00000431280 ENST00000530123	H0YCB1 [Direct mapping] Nuclear receptor-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		168 aa 18.3 kDa	No	0
NRBP2-010 ENSP00000432374 ENST00000530347	E9PR11 [Direct mapping] Nuclear receptor-binding protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	232 aa 26.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.