Expression of PRSS57 in cancer - Summary - The Human Protein Atlas

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PRSS57

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	PRSS57
Gene description	Protease, serine, 57
Protein class	Enzymes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (pancreatic cancer)
HPA (cell line):	Group enriched (NB-4, THP-1)
HPA (normal tissue):	Tissue enriched (bone marrow)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (pancreatic cancer)

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	PRSS57 (HGNC Symbol)
Synonyms	PRSSL1, UNQ782
Description	Protease, serine, 57 (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	685546 - 695498
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185198 (version 83.38)
Entrez gene	400668
UniProt	Q6UWY2 (UniProt - Evidence at protein level)
neXtProt	NX_Q6UWY2
Antibodypedia	PRSS57 antibodies

PROTEIN BROWSER

PRSS57-001	PRSS57-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRSS57-001 ENSP00000482358 ENST00000613411	Q6UWY2 [Direct mapping] Serine protease 57 Show all	Enzymes Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005576 [extracellular region] GO:0006508 [proteolysis] Show all	283 aa 30.3 kDa	Yes	0
PRSS57-002 ENSP00000327386 ENST00000329267	A0A0A0MR61 [Direct mapping] Serine protease 57 Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	282 aa 30.3 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.