Expression of SPPL2C in cancer - Summary - The Human Protein Atlas

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SPPL2C

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	SPPL2C
Gene description	Signal peptide peptidase like 2C
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (testis)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	SPPL2C (HGNC Symbol)
Synonyms	IMP5
Description	Signal peptide peptidase like 2C (HGNC Symbol)
Entrez gene summary
Chromosome	17
Cytoband	q21.31
Chromosome location (bp)	45844835 - 45847072
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185294 (version 83.38)
Entrez gene	162540
UniProt	Q8IUH8 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IUH8
Antibodypedia	SPPL2C antibodies

PROTEIN BROWSER

SPPL2C-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SPPL2C-001 ENSP00000332488 ENST00000329196	Q8IUH8 [Direct mapping] Signal peptide peptidase-like 2C Show all	Enzymes Peptidases Aspartic-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Show all	GO:0004190 [aspartic-type endopeptidase activity] GO:0005789 [endoplasmic reticulum membrane] GO:0016021 [integral component of membrane] GO:0042803 [protein homodimerization activity] GO:0071458 [integral component of cytoplasmic side of endoplasmic reticulum membrane] GO:0071556 [integral component of lumenal side of endoplasmic reticulum membrane] Show all	684 aa 74.5 kDa	Yes	9

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.