Expression of SFTPA2 in cancer - Summary - The Human Protein Atlas

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SFTPA2

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SFTPA2
Gene description	Surfactant protein A2
Protein class	Disease related genes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (lung cancer)
HPA (cell line):	Group enriched (BEWO, NB-4, RPMI-8226, U-2197)
HPA (normal tissue):	Tissue enriched (lung)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Highly specific cytoplasmic expression in type II pneumocytes.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Supported based on 4 antibodies. HPA042638 , HPA045752 , HPA049368 , CAB002439
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (lung cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA042638	HPA045752	HPA049368	CAB002439

GENE INFORMATION
Gene name	SFTPA2 (HGNC Symbol)
Synonyms	COLEC5, SP-A2
Description	Surfactant protein A2 (HGNC Symbol)
Entrez gene summary	This gene is one of several genes encoding pulmonary-surfactant associated proteins (SFTPA) located on chromosome 10. Mutations in this gene and a highly similar gene located nearby, which affect the highly conserved carbohydrate recognition domain, are associated with idiopathic pulmonary fibrosis. The current version of the assembly displays only a single centromeric SFTPA gene pair rather than the two gene pairs shown in the previous assembly which were thought to have resulted from a duplication. [provided by RefSeq, Sep 2009]
Chromosome	10
Cytoband	q22.3
Chromosome location (bp)	79555852 - 79560397
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185303 (version 83.38)
Entrez gene	729238
UniProt	Q8IWL1 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IWL1
Antibodypedia	SFTPA2 antibodies

PROTEIN BROWSER

SFTPA2-001	SFTPA2-003	SFTPA2-006	SFTPA2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SFTPA2-001 ENSP00000361400 ENST00000372325	Q8IWL1 [Direct mapping] Pulmonary surfactant-associated protein A2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Show all	GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005581 [collagen trimer] GO:0005615 [extracellular space] GO:0005789 [endoplasmic reticulum membrane] GO:0007585 [respiratory gaseous exchange] GO:0030246 [carbohydrate binding] GO:0042599 [lamellar body] GO:0044267 [cellular protein metabolic process] GO:0045334 [clathrin-coated endocytic vesicle] Show all	248 aa 26.2 kDa	Yes	0
SFTPA2-003 ENSP00000397375 ENST00000417041	X6REF7 [Direct mapping] Pulmonary surfactant-associated protein A2 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		158 aa 15.9 kDa	Yes	0
SFTPA2-006 ENSP00000473275 ENST00000492049	R4GMN3 [Direct mapping] Pulmonary surfactant-associated protein A2 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		98 aa 9.4 kDa	Yes	0
SFTPA2-201 ENSP00000361402 ENST00000372327	Q8IWL1 [Direct mapping] Pulmonary surfactant-associated protein A2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Show all	GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005581 [collagen trimer] GO:0005615 [extracellular space] GO:0005789 [endoplasmic reticulum membrane] GO:0007585 [respiratory gaseous exchange] GO:0030246 [carbohydrate binding] GO:0042599 [lamellar body] GO:0044267 [cellular protein metabolic process] GO:0045334 [clathrin-coated endocytic vesicle] Show all	248 aa 26.2 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.