Expression of HS6ST3 in cancer - Summary - The Human Protein Atlas

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HS6ST3

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	HS6ST3
Gene description	Heparan sulfate 6-O-sulfotransferase 3
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enriched (RT4)
HPA (normal tissue):	Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at transcript level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	HS6ST3
Synonyms
Description	Heparan sulfate 6-O-sulfotransferase 3 (HGNC Symbol)
Entrez gene summary	Heparan sulfate (HS) sulfotransferases, such as HS6ST3, modify HS to generate structures required for interactions between HS and a variety of proteins. These interactions are implicated in proliferation and differentiation, adhesion, migration, inflammation, blood coagulation, and other diverse processes (Habuchi et al., 2000 [PubMed 10644753]).[supplied by OMIM, Mar 2008]
Chromosome	13
Cytoband	q32.1
Chromosome location (bp)	96090839 - 96839562
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000185352 (version 83.38)
Entrez gene	266722
UniProt	Q8IZP7 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8IZP7
Antibodypedia	HS6ST3 antibodies

PROTEIN BROWSER

HS6ST3-001	HS6ST3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HS6ST3-001 ENSP00000365895 ENST00000376705	Q8IZP7 [Direct mapping] Heparan-sulfate 6-O-sulfotransferase 3 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0008146 [sulfotransferase activity] GO:0015015 [heparan sulfate proteoglycan biosynthetic process, enzymatic modification] GO:0016021 [integral component of membrane] GO:0017095 [heparan sulfate 6-O-sulfotransferase activity] Show all	471 aa 54.8 kDa	Yes	0
HS6ST3-201 ENSP00000483366 ENST00000620595	A0A087X0G1 [Direct mapping] Heparan-sulfate 6-O-sulfotransferase 3 Show all	Predicted intracellular proteins Show all	GO:0008146 [sulfotransferase activity] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] Show all	236 aa 28.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.