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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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HGS
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

HGS

Gene description

Hepatocyte growth factor-regulated tyrosine kinase substrate

Protein class

Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression at variable levels in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Pending external verification.

Reliability score

Uncertain based on 2 antibodies.
HPA004872 , HPA007728
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PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable) and cervical cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
Cervical cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA004872
HPA007728

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

A majority of malignancies showed moderate to strong cytoplasmic immunoreactivity. Malignant lymphomas, lung, skin, renal, gastric, pancreatic and liver cancers were in general weakly stained or negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Weak cytoplasmic staining in a few malignancies e.g melanomas, urothelial, and pancreatic cancers. Virtually no staining in other cancer tissues.

GENE INFORMATION

Gene name

HGS (HGNC Symbol)

Synonyms

Hrs, Vps27, ZFYVE8

Description

Hepatocyte growth factor-regulated tyrosine kinase substrate (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation. [provided by RefSeq, Dec 2010]

Chromosome

17

Cytoband

q25.3

Chromosome location (bp)

81683326 - 81703138

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000185359 (version 83.38)

Entrez gene

9146

UniProt

O14964 (UniProt - Evidence at protein level)

neXtProt

NX_O14964

Antibodypedia

HGS antibodies

PROTEIN BROWSER

HGS-001
HGS-003
HGS-008
HGS-011
HGS-013
HGS-017
HGS-018

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HGS-001
ENSP00000331201
ENST00000329138
O14964 [Direct mapping]
Hepatocyte growth factor-regulated tyrosine kinase substrate
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005829 [cytosol]
GO:0006622 [protein targeting to lysosome]
GO:0006886 [intracellular protein transport]
GO:0006892 [post-Golgi vesicle-mediated transport]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0008285 [negative regulation of cell proliferation]
GO:0010324 [membrane invagination]
GO:0010628 [positive regulation of gene expression]
GO:0016197 [endosomal transport]
GO:0019904 [protein domain specific binding]
GO:0031901 [early endosome membrane]
GO:0032585 [multivesicular body membrane]
GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway]
GO:0042176 [regulation of protein catabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043405 [regulation of MAP kinase activity]
GO:0046426 [negative regulation of JAK-STAT cascade]
GO:0046872 [metal ion binding]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:0072657 [protein localization to membrane]
GO:1903543 [positive regulation of exosomal secretion]
Show all
777 aa
86.2 kDa
No 0
HGS-003
ENSP00000459685
ENST00000571518
I3L2H4 [Direct mapping]
Hepatocyte growth factor-regulated tyrosine kinase substrate
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0006886 [intracellular protein transport]
Show all
59 aa
7 kDa
No 0
HGS-008
ENSP00000458987
ENST00000572392
I3L1P5 [Direct mapping]
Hepatocyte growth factor-regulated tyrosine kinase substrate
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0006886 [intracellular protein transport]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0046872 [metal ion binding]
Show all
263 aa
30 kDa
No 0
HGS-011
ENSP00000458603
ENST00000577012
I3L165 [Direct mapping]
Hepatocyte growth factor-regulated tyrosine kinase substrate
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0006886 [intracellular protein transport]
Show all
71 aa
8.4 kDa
No 0
HGS-013
ENSP00000458775
ENST00000571237
I3L1E3 [Direct mapping]
Hepatocyte growth factor-regulated tyrosine kinase substrate
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
292 aa
32.4 kDa
No 0
HGS-017
ENSP00000460130
ENST00000575078
I3L326 [Direct mapping]
Hepatocyte growth factor-regulated tyrosine kinase substrate
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
110 aa
12 kDa
No 0
HGS-018
ENSP00000458789
ENST00000573320
I3L1F1 [Direct mapping]
Hepatocyte growth factor-regulated tyrosine kinase substrate
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
63 aa
6.8 kDa
No 0

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