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MAPK11

GENERAL INFORMATION

Gene name

 MAPK11

Gene description

 Mitogen-activated protein kinase 11

Protein class

 Enzymes
FDA approved drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression often in a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA045069 , CAB012961
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA045069
CAB012961

GENE INFORMATION

Gene name

 MAPK11 (HGNC Symbol)

Synonyms

 p38-2, p38Beta, PRKM11, SAPK2

Description

 Mitogen-activated protein kinase 11 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of a family of protein kinases that are involved in the integration of biochemical signals for a wide variety of cellular processes, including cell proliferation, differentiation, transcriptional regulation, and development. The encoded protein can be activated by proinflammatory cytokines and environmental stresses through phosphorylation by mitogen activated protein kinase kinases (MKKs). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Chromosome

 22

Cytoband

 q13.33

Chromosome location (bp)

 50263713 - 50270767

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000185386 (version 83.38)

Entrez gene

 5600

UniProt

 Q15759 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15759

Antibodypedia

 MAPK11 antibodies

PROTEIN BROWSER
MAPK11-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MAPK11-001
ENSP00000333685
ENST00000330651
Q15759 [Direct mapping]
Mitogen-activated protein kinase 11
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000187 [activation of MAPK activity]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006950 [response to stress]
GO:0006996 [organelle organization]
GO:0007005 [mitochondrion organization]
GO:0007165 [signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0010467 [gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035556 [intracellular signal transduction]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042692 [muscle cell differentiation]
GO:0043488 [regulation of mRNA stability]
GO:0045087 [innate immune response]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0051149 [positive regulation of muscle cell differentiation]
GO:0051403 [stress-activated MAPK cascade]
GO:0060043 [regulation of cardiac muscle cell proliferation]
GO:0060044 [negative regulation of cardiac muscle cell proliferation]
GO:0098586 [cellular response to virus]
GO:2001184 [positive regulation of interleukin-12 secretion]
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 364 aa
41.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.