Expression of IFNLR1 in cancer - Summary - The Human Protein Atlas

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IFNLR1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	IFNLR1
Gene description	Interferon, lambda receptor 1
Protein class	Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (U-266/70, U-698)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results.
Reliability score	Uncertain based on 1 antibody. HPA017319
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PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (favourable).
Breast cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA017319

GENE INFORMATION
Gene name	IFNLR1 (HGNC Symbol)
Synonyms	CRF2/12, IFNLR, IL-28R1, IL28RA
Description	Interferon, lambda receptor 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	p36.11
Chromosome location (bp)	24154157 - 24187959
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185436 (version 83.38)
Entrez gene	163702
UniProt	Q8IU57 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IU57
Antibodypedia	IFNLR1 antibodies

PROTEIN BROWSER

IFNLR1-001	IFNLR1-002	IFNLR1-003	IFNLR1-004	IFNLR1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IFNLR1-001 ENSP00000327824 ENST00000327535	Q8IU57 [Direct mapping] Interferon lambda receptor 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0002385 [mucosal immune response] GO:0004896 [cytokine receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0008285 [negative regulation of cell proliferation] GO:0016021 [integral component of membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0032002 [interleukin-28 receptor complex] GO:0034342 [response to type III interferon] GO:0050691 [regulation of defense response to virus by host] GO:0051607 [defense response to virus] Show all	520 aa 57.7 kDa	Yes	1
IFNLR1-002 ENSP00000363542 ENST00000374421	Q8IU57 [Direct mapping] Interferon lambda receptor 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0002385 [mucosal immune response] GO:0004896 [cytokine receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0008285 [negative regulation of cell proliferation] GO:0016021 [integral component of membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0032002 [interleukin-28 receptor complex] GO:0034342 [response to type III interferon] GO:0050691 [regulation of defense response to virus by host] GO:0051607 [defense response to virus] Show all	491 aa 54.4 kDa	Yes	1
IFNLR1-003 ENSP00000328994 ENST00000327575	Q8IU57 [Direct mapping] Interferon lambda receptor 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0002385 [mucosal immune response] GO:0004896 [cytokine receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0008285 [negative regulation of cell proliferation] GO:0016021 [integral component of membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0032002 [interleukin-28 receptor complex] GO:0034342 [response to type III interferon] GO:0050691 [regulation of defense response to virus by host] GO:0051607 [defense response to virus] Show all	244 aa 27.5 kDa	Yes	0
IFNLR1-004 ENSP00000363539 ENST00000374418	Q8IU57 [Direct mapping] Interferon lambda receptor 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0002385 [mucosal immune response] GO:0004896 [cytokine receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0008285 [negative regulation of cell proliferation] GO:0016021 [integral component of membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0032002 [interleukin-28 receptor complex] GO:0034342 [response to type III interferon] GO:0050691 [regulation of defense response to virus by host] GO:0051607 [defense response to virus] Show all	211 aa 23.7 kDa	Yes	0
IFNLR1-005 ENSP00000363540 ENST00000374419	Q5VTX9 [Direct mapping] Interferon lambda receptor 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004896 [cytokine receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0019221 [cytokine-mediated signaling pathway] Show all	185 aa 20.9 kDa	No	1

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The Human Protein Atlas

The Human Protein Atlas project is funded
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