Expression of SH3BGR in cancer - Summary - The Human Protein Atlas

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SH3BGR

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SH3BGR
Gene description	SH3 domain binding glutamate-rich protein
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (U-87 MG)
HPA (normal tissue):	Group enriched (heart muscle, skeletal muscle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in heart and skeletal muscle.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 2 antibodies. HPA030690 , CAB003685
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA030690	CAB003685

GENE INFORMATION
Gene name	SH3BGR (HGNC Symbol)
Synonyms	21-GARP
Description	SH3 domain binding glutamate-rich protein (HGNC Symbol)
Entrez gene summary
Chromosome	21
Cytoband	q22.2
Chromosome location (bp)	39445855 - 39515506
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185437 (version 83.38)
Entrez gene	6450
UniProt	P55822 (UniProt - Evidence at transcript level)
neXtProt	NX_P55822
Antibodypedia	SH3BGR antibodies

PROTEIN BROWSER

SH3BGR-001	SH3BGR-002	SH3BGR-004	SH3BGR-005	SH3BGR-006	SH3BGR-007	SH3BGR-008	SH3BGR-009	SH3BGR-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SH3BGR-001 ENSP00000332513 ENST00000333634	P55822 [Direct mapping] SH3 domain-binding glutamic acid-rich protein Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005070 [SH3/SH2 adaptor activity] GO:0005829 [cytosol] GO:0006461 [protein complex assembly] GO:0009967 [positive regulation of signal transduction] GO:0017124 [SH3 domain binding] Show all	239 aa 26.1 kDa	No	0
SH3BGR-002 ENSP00000370011 ENST00000380637	P55822 [Direct mapping] SH3 domain-binding glutamic acid-rich protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005070 [SH3/SH2 adaptor activity] GO:0005829 [cytosol] GO:0006461 [protein complex assembly] GO:0009967 [positive regulation of signal transduction] GO:0017124 [SH3 domain binding] Show all	128 aa 14 kDa	No	0
SH3BGR-004 ENSP00000404980 ENST00000458295	C9JJT2 [Direct mapping] SH3 domain-binding glutamic acid-rich protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		97 aa 10.7 kDa	No	0
SH3BGR-005 ENSP00000401572 ENST00000440288	C9JX40 [Direct mapping] SH3 domain-binding glutamic acid-rich protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		106 aa 11.6 kDa	No	0
SH3BGR-006 ENSP00000370005 ENST00000380631	P55822 [Direct mapping] SH3 domain-binding glutamic acid-rich protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005070 [SH3/SH2 adaptor activity] GO:0005829 [cytosol] GO:0006461 [protein complex assembly] GO:0009967 [positive regulation of signal transduction] GO:0017124 [SH3 domain binding] Show all	128 aa 14 kDa	No	0
SH3BGR-007 ENSP00000370008 ENST00000380634	P55822 [Direct mapping] SH3 domain-binding glutamic acid-rich protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005070 [SH3/SH2 adaptor activity] GO:0005829 [cytosol] GO:0006461 [protein complex assembly] GO:0009967 [positive regulation of signal transduction] GO:0017124 [SH3 domain binding] Show all	128 aa 14 kDa	No	0
SH3BGR-008 ENSP00000405675 ENST00000452550	H7C2G0 [Direct mapping] SH3 domain-binding glutamic acid-rich protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		137 aa 15.2 kDa	No	0
SH3BGR-009 ENSP00000403115 ENST00000447939	H7C1Y8 [Direct mapping] SH3 domain-binding glutamic acid-rich protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		54 aa 5.9 kDa	No	0
SH3BGR-010 ENSP00000413981 ENST00000423596	H7C3V3 [Direct mapping] SH3 domain-binding glutamic acid-rich protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		81 aa 8.7 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.