Expression of FAM174B in cancer - Summary - The Human Protein Atlas

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FAM174B

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FAM174B
Gene description	Family with sequence similarity 174, member B
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (MCF7, RPMI-8226, RT4)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA015306
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable).
Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA015306

GENE INFORMATION
Gene name	FAM174B (HGNC Symbol)
Synonyms	LOC400451, MGC102891
Description	Family with sequence similarity 174, member B (HGNC Symbol)
Entrez gene summary
Chromosome	15
Cytoband	q26.1
Chromosome location (bp)	92617443 - 92809884
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185442 (version 83.38)
Entrez gene	400451
UniProt	Q3ZCQ3 (UniProt - Evidence at transcript level)
neXtProt	NX_Q3ZCQ3
Antibodypedia	FAM174B antibodies

PROTEIN BROWSER

FAM174B-001	FAM174B-003	FAM174B-004	FAM174B-005	FAM174B-006	FAM174B-007	FAM174B-009	FAM174B-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FAM174B-001 ENSP00000329040 ENST00000327355	Q3ZCQ3 [Direct mapping] Membrane protein FAM174B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	159 aa 17 kDa	Yes	1
FAM174B-003 ENSP00000452295 ENST00000555748	G3V5D1 [Direct mapping] Membrane protein FAM174B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		113 aa 12.8 kDa	No	0
FAM174B-004 ENSP00000456619 ENST00000555696	G3V5D1 [Direct mapping] Membrane protein FAM174B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		113 aa 12.8 kDa	No	0
FAM174B-005 ENSP00000455517 ENST00000556824	H3BPY1 [Direct mapping] Membrane protein FAM174B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		91 aa 10.4 kDa	No	0
FAM174B-006 ENSP00000455213 ENST00000557480	H3BP98 [Direct mapping] Membrane protein FAM174B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		109 aa 12.3 kDa	No	0
FAM174B-007 ENSP00000455765 ENST00000555064	G3V5D1 [Direct mapping] Membrane protein FAM174B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		113 aa 12.8 kDa	No	0
FAM174B-009 ENSP00000457201 ENST00000553393	H3BTJ4 [Direct mapping] Membrane protein FAM174B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		37 aa 4.1 kDa	No	0
FAM174B-015 ENSP00000456099 ENST00000557398	H3BR69 [Direct mapping] Membrane protein FAM174B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		67 aa 7.5 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.