Expression of GPRIN3 in cancer - Summary

GENERAL INFORMATION
Gene name	GPRIN3
Gene description	GPRIN family member 3
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (Karpas-707, RPMI-8226, SCLC-21H)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous and cytoplasmic expression in several tissues including islets of Langerhans, CNS and subsets of cells in tonsil.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA057666 , HPA059092
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (favourable) and renal cancer (favourable).
Colorectal cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA057666	HPA059092

GENE INFORMATION
Gene name	GPRIN3 (HGNC Symbol)
Synonyms	FLJ42625, GRIN3
Description	GPRIN family member 3 (HGNC Symbol)
Entrez gene summary
Chromosome	4
Cytoband	q22.1
Chromosome location (bp)	89236386 - 89308010
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185477 (version 83.38)
Entrez gene	285513
UniProt	Q6ZVF9 (UniProt - Evidence at transcript level)
neXtProt	NX_Q6ZVF9
Antibodypedia	GPRIN3 antibodies

PROTEIN BROWSER

GPRIN3-001	GPRIN3-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GPRIN3-001 ENSP00000476603 ENST00000609438	Q6ZVF9 [Direct mapping] G protein-regulated inducer of neurite outgrowth 3 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all		776 aa 82.4 kDa	No	0
GPRIN3-002 ENSP00000328672 ENST00000333209	Q6ZVF9 [Direct mapping] G protein-regulated inducer of neurite outgrowth 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		776 aa 82.4 kDa	No	0